Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2021 May;82(5):186-230.
doi: 10.1016/j.jinf.2020.11.041. Epub 2020 Dec 2.

Role of endothelial dysfunction in the thrombotic complications of COVID-19 patients

Emanuela Falcinelli  1 , Eleonora Petito  1 , Cecilia Becattini  1 , Edoardo De Robertis  2 , Ugo Paliani  3 , Manuela Sebastiano  1 , Gaetano Vaudo  4 , Giuseppe Guglielmini  1 , Francesco Paciullo  1 , Vittorio Cerotto  5 , Marco Malvestiti  1 , Fabio Gori  6 , Loredana Bury  1 , Teseo Lazzarini  7 , Paolo Gresele  8 ; COVIR study investigators
Affiliations
Comment

Role of endothelial dysfunction in the thrombotic complications of COVID-19 patients

Emanuela Falcinelli et al. J Infect. 2021 May.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Declaration of Competing Interest The authors declare no conflict of interest.

Figures

Fig 1
Fig. 1
Cellular and soluble markers of endothelial dysfunction in COVID-19 samples. Subpopulations of circulating EPCs based on CD45 expression: angioblast EPCs CD45neg (A) and hematopoietic EPCs CD45+int (B) in COVID-19 patients and in healthy controls. Results are expressed as absolute number/μl. *=p<0.05 vs healthy controls. sICAM-1 (C) levels are increased in COVID-19 patients compared to healthy controls (p<0.05) and in plasma of COVID-19 patients admitted into intensive care unit (ICU) or in non-ICU COVID-19 wards (p<0.05) (D), with normal or abnormal PaO2/FIO2 ratio (p<0.05) (E) and patients with or without thromboembolic event (p<0.05) (F). (*=p<0.05).
See this image and copyright information in PMC

Comment in

Comment on

References

    1. Kunutsor S.K., Laukkanen J.A. Cardiovascular complications in COVID-19: a systematic review and meta-analysis. J Infect. 2020;81:e139–e141. doi: 10.1016/j.jinf.2020.05.068. Epub 2020 Jun 3PMID: 32504747. - DOI - PMC - PubMed
    1. Nopp S., Moik F., Jilma B., Pabinger I., Ay C. Risk of venous thromboembolism in patients with COVID-19: a systematic review and meta-analysis. Res Pract Thromb Haemost. 2020;4:1178–1191. - PMC - PubMed
    1. López Castro J. COVID-19 and thrombosis: beyond a casual association. Med Clin (Engl Ed) 2020;155:44. - PMC - PubMed
    1. Page A.V., Liles W.C. Biomarkers of endothelial activation/dysfunction in infectious diseases. Virulence. 2013;4:507–516. doi: 10.4161/viru.24530. - DOI - PMC - PubMed
    1. Gresele P., Migliacci R., Procacci A., De Monte P., Bonizzoni E. Prevention by NCX 4016, a nitric oxide-donating aspirin, but not by aspirin, of the acute endothelial dysfunction induced by exercise in patients with intermittent claudication. Thromb Haemost. 2007;97:444–450. - PubMed