Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Dec 4;20(1):1862.
doi: 10.1186/s12889-020-09984-9.

Prevalence of syphilis, neurosyphilis and associated factors in a cross-sectional analysis of HIV infected patients attending Bugando Medical Centre, Mwanza, Tanzania

Adeodatus Haule  1 , Betrand Msemwa  2 , Evarista Mgaya  3 , Peter Masikini  4 , Samuel Kalluvya  4
Affiliations

Prevalence of syphilis, neurosyphilis and associated factors in a cross-sectional analysis of HIV infected patients attending Bugando Medical Centre, Mwanza, Tanzania

Adeodatus Haule et al. BMC Public Health. .

Abstract

Background: HIV-syphilis co-infection can enhance the rapid progression of early or late latent syphilis to neurosyphilis and can cause catastrophic neurological complications. In studies in Mwanza, syphilis affects ~ 8% of healthy outpatients and studies done in the 1990s have suggested that up to 23.5% of HIV-syphilis co-infected patients also have neurosyphilis.

Methodology: This was a cross sectional study in which adult HIV infected patients who were hospitalized or attending the outpatient Care and Treatment Clinic (CTC) were interviewed using a structured questionnaire and screened for syphilis using serum Treponema Pallidum Hemagglutination Assay (TPHA). Blood was also taken for CD4+ T cells and viral load. Those who were found to have syphilis underwent neurological examination for any neurologic deficit and were offered a lumbar puncture.

Results: The prevalence of syphilis in HIV infected patients was found to be 9.6%. The majority of patients were female (72.5%) and median age was 42 years [interquartile range, 32-50]. Most patients were on ART (99.4%). In the study population of 1748 participants, 9.6% were TPHA positive; the majority (89.2%) reported not knowing their syphilis status and not previously been treated. One hundred and forty-one participants with syphilis had neurological examinations performed. Four of these had abnormal findings that necessitated a lumbar puncture. Neurosyphilis was confirmed in one patient (0.7%).

Conclusion: The high prevalence of syphilis in HIV infected patients indicates that there is a need to increase efforts in targeting this population to reduce sexually transmitted infections. Screening for syphilis should be done for all HIV patients given the high prevalence of the infection and the risk that aggressive forms of neurosyphilis can occur despite recovery of CD4+ T cell counts in untreated syphilis.

Keywords: Human immunodeficiency virus; Human immunodeficiency virus- Treponema pallidum co-infection; Neurosyphilis; Syphilis.

PubMed Disclaimer

Conflict of interest statement

Not applicable.

References

    1. Newman L, Rowley J, Vander Hoorn S, Wijesooriya NS, Unemo M, Low N, et al. Global estimates of the prevalence and incidence of four curable sexually transmitted infections in 2012 based on systematic review and global reporting. PLoS One. 2015;10(12):1–17. - PMC - PubMed
    1. Kenyon CR, Osbak K, Tsoumanis A. The Global Epidemiology of Syphilis in the Past Century.A SystematicReview Based on Antenatal Syphilis Prevalence. PLOS Neg Trop Dis. 2016;10(5);2016:1–23. - PMC - PubMed
    1. Manyahi J, Jullu BS, Abuya MI, Juma J, Ndayongeje J, Kilama B, et al. Prevalence of HIV and syphilis infections among pregnant women attending antenatal clinics in Tanzania, 2011. BMC Public Health. 2015;15:501. doi: 10.1186/s12889-015-1848-5. - DOI - PMC - PubMed
    1. Downs JA, Van Dam GJ, Changalucha JM, Corstjens PLAM, Peck RN, De Dood CJ, et al. Association of schistosomiasis and HIV infection in Tanzania. Am J Trop Med Hyg. 2012;87(5):868–873. doi: 10.4269/ajtmh.2012.12-0395. - DOI - PMC - PubMed
    1. Funnye AS, Akhtar AJ, Uk DV. Syphilis and human immunodeficiency virus co-infection. J Natl Med Assoc. 2003;95:363–382. - PMC - PubMed