Randomized trials, observational studies, and the illusive search for the source of truth

Affiliations

¹ Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY.
² Center for Biostatistics, Icahn School of Medicine at Mount Sinai, New York, NY.
³ Department of Surgery, Center for Innovation and Outcomes Research, Columbia University Medical Center, New York, NY. Electronic address: pk2245@cumc.columbia.edu.

Free article

Editorial

Mario Gaudino et al. J Thorac Cardiovasc Surg. 2022 Feb.

Free article

. 2022 Feb;163(2):757-762.

doi: 10.1016/j.jtcvs.2020.10.120. Epub 2020 Nov 10.

¹ Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY.
² Center for Biostatistics, Icahn School of Medicine at Mount Sinai, New York, NY.
³ Department of Surgery, Center for Innovation and Outcomes Research, Columbia University Medical Center, New York, NY. Electronic address: pk2245@cumc.columbia.edu.

No abstract available

Keywords: comparative effectiveness research; observational studies; randomized trials.

Comment in

Commentary: Looking for certainties, finding uncertainties.
Barili F, Parolari A. Barili F, et al. J Thorac Cardiovasc Surg. 2022 Feb;163(2):763. doi: 10.1016/j.jtcvs.2020.12.007. Epub 2020 Dec 9. J Thorac Cardiovasc Surg. 2022. PMID: 33422321 No abstract available.
Commentary: In pursuit of the truth for applying randomized controlled trial results to individual patients.
Zurakowski D, Dwyer WJ, Staffa SJ. Zurakowski D, et al. J Thorac Cardiovasc Surg. 2022 Feb;163(2):764-765. doi: 10.1016/j.jtcvs.2020.12.060. Epub 2021 Jan 26. J Thorac Cardiovasc Surg. 2022. PMID: 33514471 No abstract available.