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Comment
. 2021 Mar;99(3):252-254.
doi: 10.1111/imcb.12424. Epub 2020 Dec 4.

Antigen-driven CD4+ T-cell anergy: a pathway to peripheral T regulatory cells

Peter J Eggenhuizen  1 , Boaz H Ng  1 , Joshua D Ooi  1
Affiliations
Comment

Antigen-driven CD4+ T-cell anergy: a pathway to peripheral T regulatory cells

Peter J Eggenhuizen et al. Immunol Cell Biol. 2021 Mar.

Abstract

In their recent publication, Kuczma and colleagues have provided evidence that advances the relationship between naive T cells, T cell anergy and T regulatory cells. Their findings strengthen the understanding of how these T cell subsets function in relation to self and microbiota-derived epitopes to promote and maintain peripheral tolerance to self and mucosal antigens.

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References

    1. Kuczma MP, Szurek EA, Cebula A, et al. Self and microbiota-derived epitopes induce CD4+ T cell anergy and conversion into CD4+Foxp3+ regulatory cells. Mucosal Immunology. 2020. https://doi.org/10.1038/s41385-020-00349-4
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