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Review
. 2021 Feb 1;27(1):46-54.
doi: 10.1097/MCC.0000000000000786.

Biomarkers in acute respiratory distress syndrome

Matthieu Jabaudon  1   2   3 , Raiko Blondonnet  1   2 , Lorraine B Ware  3   4
Affiliations
Review

Biomarkers in acute respiratory distress syndrome

Matthieu Jabaudon et al. Curr Opin Crit Care. .

Abstract

Purpose of review: This article provides an overview of protein biomarkers for acute respiratory distress syndrome (ARDS) and their potential use in future clinical trials.

Recent findings: The protein biomarkers studied as indices of biological processes involved in the pathogenesis of ARDS may have diagnostic and/or prognostic value. Recently, they also proved useful for identifying ARDS phenotypes and assessing heterogeneity of treatment effect in retrospective analyses of completed clinical trials.

Summary: This article summarizes the current research on ARDS biomarkers and provides insights into how they should be integrated as prognostic and predictive enrichment tools in future clinical trials.

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Conflict of interest statement

The authors declare that there is no conflict of interest regarding the publication of this paper.

Figures

Figure
Figure. Schematic representation of the value of selected protein biomarkers for diagnosis of acute respiratory distress syndrome and potential application for predictive and prognostic trial enrichment.
KL-6: Krebs von den Lungen 6. PCT: procalcitonin. IL: interleukin. SP-D: surfactant protein D. sICAM-1: soluble intercellular adhesion molecule-1. CC16: club cell secretory protein. PAI-1: plasminogen activator inhibitor-1. vWF: von Willebrand factor. BNP: brain natriuretic peptide. sRAGE: soluble receptor for advanced glycation end-products. sTNFr: soluble tumor necrosis factor receptor. Ang: angiopoietin. TNF: tumor necrosis factor. PCP3: procollagen peptide III.
See this image and copyright information in PMC

References

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    2. ** A recent review on ARDS, with major insights on pathophysiologic mechanisms and potential biomarkers.

    1. Jabaudon M, Blondonnet R, Audard J, et al. Recent directions in personalised acute respiratory distress syndrome medicine. Anaesth Crit Care Pain Med. 2018. June;37(3):251–8. - PubMed

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