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. 2021 Apr;56(4):989-991.
doi: 10.1038/s41409-020-01158-w. Epub 2020 Dec 5.

Longitudinal tracking of skin dynamic stiffness to quantify evolution of sclerosis in chronic graft-versus-host disease

Laura X Baker  1   2 , Fuyao Chen  1   2   3   4 , Yvette Ssempijja  1   2   5 , Michael Byrne  6 , Tae Kon Kim  6 , Arved Vain  7 , Madan Jagasia  8 , Eric R Tkaczyk  9   10   11   12
Affiliations

Longitudinal tracking of skin dynamic stiffness to quantify evolution of sclerosis in chronic graft-versus-host disease

Laura X Baker et al. Bone Marrow Transplant. 2021 Apr.
No abstract available

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Conflict of interest statement

Competing Interests:

The authors declare no competing financial interests. A.V. is the inventor of the Myoton but has no financial interest in the device.

Figures

Figure 1.
Figure 1.. Average dynamic stiffness measurements and linear regression slopes.
(A) Dynamic stiffness measurements (N/m) over time of a representative sclerotic cGVHD patient from each clinically-determined response type: partial response (PR), stable disease (SD), and progressive disease (PD), and one cGVHD patient with no skin symptoms. Simple linear regression lines are shown in bold. (B) Regression slopes of dynamic stiffness measurements over time in N/m/month for ten sclerotic cGVHD patients (patients 1–10) and two cGVHD patients without skin manifestations (patients 11, 12).
See this image and copyright information in PMC

References

    1. Inamoto Y, Storer BE, Petersdorf EW, Nelson JL, Lee SJ, Carpenter PA, et al. Incidence risk factors, and outcomes of sclerosis in patients with chronic graft-versus-host disease. Blood. 2013;121(25):5098–5103. - PMC - PubMed
    1. Lee SJ, Wolff D, Kitko C, Koreth J, Inamoto Y, Jagasia M, et al. Measuring therapeutic response in chronic graft-versus-host disease. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: IV. The 2014 Response Criteria Working Group report. Biol Blood Marrow Transplant. 2015;21(6):984–999. - PMC - PubMed
    1. Cowen EW. Decoding skin involvement in chronic graft-vs-host disease. JAMA Dermatol. 2019;155(7):777–778. - PubMed
    1. Vain A, inventor; Myoton AS, assignee. Device and method for real-time measurement of parameters of mechanical stress state and biomechanical properties of soft biological tissue. United States patent application US 13/977,873. 2011.
    1. Chen F, Dellalana LE, Gandelman JS, Vain A, Jagasia MH, Tkaczyk ER. Non-invasive measurement of sclerosis in cutaneous cGVHD patients with the handheld device Myoton: a cross-sectional study. Bone Marrow Transplant. 2019;54(4):616–619. - PMC - PubMed

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