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Comment
. 2021 Mar;99(3):249-251.
doi: 10.1111/imcb.12421. Epub 2020 Dec 6.

Transforming growth factor β in breast cancer: another new trick for the old dog

Kun-Hui Lu  1   2 , Shom Goel  1   2
Affiliations
Comment

Transforming growth factor β in breast cancer: another new trick for the old dog

Kun-Hui Lu et al. Immunol Cell Biol. 2021 Mar.

Abstract

Two recent papers from the laboratory of Professor Ming Li demonstrate that inhibition of transforming growth factor β specifically in CD4+ T cells can suppress tumor growth through an unanticipated mechanism.

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Comment on

  • TGF-β suppresses type 2 immunity to cancer.
    Liu M, Kuo F, Capistrano KJ, Kang D, Nixon BG, Shi W, Chou C, Do MH, Stamatiades EG, Gao S, Li S, Chen Y, Hsieh JJ, Hakimi AA, Taniuchi I, Chan TA, Li MO. Liu M, et al. Nature. 2020 Nov;587(7832):115-120. doi: 10.1038/s41586-020-2836-1. Epub 2020 Oct 21. Nature. 2020. PMID: 33087928 Free PMC article.
  • Cancer immunotherapy via targeted TGF-β signalling blockade in TH cells.
    Li S, Liu M, Do MH, Chou C, Stamatiades EG, Nixon BG, Shi W, Zhang X, Li P, Gao S, Capistrano KJ, Xu H, Cheung NV, Li MO. Li S, et al. Nature. 2020 Nov;587(7832):121-125. doi: 10.1038/s41586-020-2850-3. Epub 2020 Oct 21. Nature. 2020. PMID: 33087933 Free PMC article.

References

REFERENCES

    1. Roberts AB, Anzano MA, Lamb LC, et al. Isolation from murine sarcoma cells of novel transforming growth factors potentiated by EGF. Nature 1982; 295: 417-419.
    1. Connolly EC, Freimuth J, Akhurst RJ. Complexities of TGF-β targeted cancer therapy. Int J Biol Sci 2012; 8: 964-978.
    1. Groeneveldt C, van Hall T, van der Burg SH, Ten Dijke P, van Montfoort N. Immunotherapeutic potential of TGF-β inhibition and oncolytic viruses. Trends Immunol 2020; 41: 406-420.
    1. Derynck R, Turley SJ, Akhurst RJ. TGFβ biology in cancer progression and immunotherapy. Nat Rev Clin Oncol 2021; 18: 9-34.
    1. Liu M, Kuo F, Capistrano KJ, et al. TGF-β suppresses type 2 immunity to cancer. Nature 2020; 587 (7832): 115-120.

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