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Case Reports
. 2021 Jan:83:119-122.
doi: 10.1016/j.jocn.2020.11.013. Epub 2020 Nov 14.

Guillain-Barré syndrome as a parainfectious manifestation of SARS-CoV-2 infection: A case series

Meysam Abolmaali  1 , Matineh Heidari  2 , Marjan Zeinali  2 , Parichehr Moghaddam  2 , Mona Ramezani Ghamsari  3 , Mahin Jamshidi Makiani  4 , Zahra Mirzaasgari  5
Affiliations
Case Reports

Guillain-Barré syndrome as a parainfectious manifestation of SARS-CoV-2 infection: A case series

Meysam Abolmaali et al. J Clin Neurosci. 2021 Jan.

Abstract

The global SARS-CoV-2 pandemic posed an unprecedented challenge to almost all fields of medicine and Neurology is not an exception. Collecting information about its complications and related conditions will help clinicians to become more confident in managing this disease. Guillain-Barre Syndrome (GBS) is mostly described as a post-infectious phenomenon and its occurrence during acute phase of illness is of interest. GBS has recently been reported during the active phase of COVID-19 for the first time. Severity and fast progression of GBS associated with COVID-19 have also been shown in recent studies. Here we report three cases of GBS during the active phase of COVID-19 with severe symptoms and fast progression to quadriplegia and facial diplegia over 2 days, which led to death in one case due to severe autonomic dysfunction. We suggest SARS-CoV-2 might be associated with rather a severe, rapidly progressive and life-threatening phenotype of GBS.

Keywords: COVID-19; Coronavirus; Guillain–Barré syndrome.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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