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Case Reports
. 2021 May 15;60(10):1529-1532.
doi: 10.2169/internalmedicine.6321-20. Epub 2020 Dec 7.

A Rare Case of Localized Esophageal Amyloidosis

Taku Fujiya  1 , Waku Hatta  1 , Tomoyuki Koike  1 , Yohei Ogata  1 , Masahiro Saito  1 , Xiaoyi Jin  1 , Kenichiro Nakagawa  1 , Takeshi Kanno  1 , Kiyotaka Asanuma  1 , Kaname Uno  1 , Naoki Asano  1 , Akira Imatani  1 , Fumiyoshi Fujishima  2 , Nagaaki Katoh  3 , Tsuneaki Yoshinaga  3 , Atsushi Masamune  1
Affiliations
Case Reports

A Rare Case of Localized Esophageal Amyloidosis

Taku Fujiya et al. Intern Med. .

Abstract

A 72-year-old man without any symptoms was referred to our hospital. Esophagogastroduodenoscopy revealed an elevated esophageal lesion that was covered with normal mucosa. The examination of biopsy specimens from the lesion revealed amyloid light-chain (AL) (λ) type amyloid deposits, but there were no amyloid deposits elsewhere in the gastrointestinal tract. Further examinations did not indicate systemic amyloidosis. Thus, this case was diagnosed as a localized esophageal amyloidosis. As the clinical outcome of localized amyloidosis is favorable, this case was scheduled for close follow-up. Localized amyloidosis should be considered in the differential diagnosis of esophageal submucosal tumors.

Keywords: amyloidosis; esophagus.

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Conflict of interest statement

The authors state that they have no Conflict of Interest (COI).

Figures

Figure 1.
Figure 1.
Endoscopic images of a case of localized esophageal amyloidosis. The reddish lesion is covered with a normal mucosa (A, B). Magnifying endoscopy with NBI shows green-colored dilated blood vessels (C). In EUS, a hypoechoic mass is localized in the second and third layers (D). *Biopsy specimens were acquired from these parts. NBI: narrow-band imaging, EUS: endoscopic ultrasonography
Figure 2.
Figure 2.
The microscopic findings in a case of AL (λ)-type localized esophageal amyloidosis. Hematoxylin and Eosin staining of the biopsy specimen revealed eosinophilic amorphous material in the lamina propria mucosa (A). Congo red staining of the material was positive (B) and green birefringence was observed by polarized light microscopy (C). Immunohistochemical staining for immunoglobulin λ light chain was positive (D). Bar=200 μm. AL: amyloid light chain
See this image and copyright information in PMC

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