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Case Reports
. 2020 Nov 16:2020:8877445.
doi: 10.1155/2020/8877445. eCollection 2020.

Atypical Presentation of Anti-Phospholipid Antibody Syndrome with Seizure and Atrial Mass

Rajish Sanjit Kumar Shil  1 , Amal Abdallah Al Dhuhoori  1 , Vipin Mughilassery Thomachan  2 , Jamal Ali Teir  3 , Renganathan Radhakrishnan  4
Affiliations
Case Reports

Atypical Presentation of Anti-Phospholipid Antibody Syndrome with Seizure and Atrial Mass

Rajish Sanjit Kumar Shil et al. Case Rep Med. .

Abstract

Anti-phospholipid antibody syndrome (APS) has a broad spectrum of thrombotic and nonthrombotic clinical manifestations. The diagnosis requires a set of clinical criteria of thrombosis along with persistently positive anti-phospholipid antibody tests. In this report, we are presenting a case of APS, who is a 38-year-old male, presented with complains of seizures and found to have stroke, which on further investigation revealed to have been caused possibly from a left atrial mass. Therefore, high index of suspicion is required for the diagnosis of APS in young patients, who present with various neurological and cardiovascular manifestations, mostly secondary to thrombosis.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Axial view of MRI brain showing the right cerebellar infarct.
Figure 2
Figure 2
Coronal view of MRI brain showing the right cerebellar infarct.
Figure 3
Figure 3
Coronal view of MRI brain showing the right cerebellar infarct.
Figure 4
Figure 4
Echo view showing the left atrial mass with color Doppler.
Figure 5
Figure 5
Echo view showing pedunculated left atrial mass.
Figure 6
Figure 6
Gross specimen of the clot after the surgery.
Figure 7
Figure 7
Intraoperative view, removal of the clot.
See this image and copyright information in PMC

References

    1. Tenedios F., Erkan D., Lockshin M. D. Cardiac involvement in the antiphospholipid syndrome. Lupus. 2005;14(9):691–696. doi: 10.1191/0961203305lu2202oa. - DOI - PubMed
    1. Miyakis S., Lockshin M. D., Atsumi T., et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS) Journal of Thrombosis and Haemostasis. 2006;4(2):295–306. doi: 10.1111/j.1538-7836.2006.01753.x. - DOI - PubMed
    1. Cervera R., Piette J.-C., Font J., et al. Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients. Arthritis & Rheumatism. 2002;46(4):1019–1027. doi: 10.1002/art.10187. - DOI - PubMed
    1. Plain D., Van Camp G., Efira A., et al. Intracardiac thrombi associated with antiphospholipid antibodies. Journal of the American Society of Echocardiography. 1996;9(6):891–893. doi: 10.1016/S0894-7317(96)90486-1. - DOI - PubMed
    1. Cianciulli T. F., Saccheri M. C., Redruello H. J., et al. Right atrial thrombus mimicking myxoma with pulmonary embolism in a patient with systemic lupus erythematosus and secondary antiphospholipid syndrome. Texas Heart Institute Journal. 2008;35(4):454–457. - PMC - PubMed

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