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. 2020 Nov 24:12:2036361320973526.
doi: 10.1177/2036361320973526. eCollection 2020.

Primary squamous cell carcinoma of major salivary gland: "Sapienza Head and Neck Unit" clinical recommendations

Silvia Mezi  1 , Giulia Pomati  1 , Andrea Botticelli  2 , Francesca De Felice  1 , Daniela Musio  1 , Marco Della Monaca  3 , Sasan Amirhassankhani  4 , Francesco Vullo  1 , Bruna Cerbelli  1 , Raffaella Carletti  1 , Cira Di Gioia  1 , Carlo Catalano  1 , Valentino Valentini  3 , Vincenzo Tombolini  1 , Carlo Della Rocca  5 , Paolo Marchetti  2
Affiliations

Primary squamous cell carcinoma of major salivary gland: "Sapienza Head and Neck Unit" clinical recommendations

Silvia Mezi et al. Rare Tumors. .

Abstract

Primary squamous cell carcinoma of salivary gland (SCG) is an extremely rare type of malignant salivary gland tumor, which in turn results in scarcity of data available regarding both its treatment and associated genetic alterations. A retrospective analysis of 12 patients with primary SCG was conducted, along with analysis of the association between treatment, clinical/pathological characteristics, and outcomes. Most patients (8) were staged IVa, with the majority of them (10) having G3 fast growing cancer. Local and systemic recurrence were reported in only three out of nine parotid cases (0 out of 2 submandibular SCGs). In two out of eight patients local relapse occurred after integrated treatment, while recurrence occurred in two out of three patients undergoing exclusive surgery. Five patients eventually died. Treatment of resectable disease must be aggressive and multimodal, with achievement of loco-regional control in order to reduce rate of recurrence and improve outcomes. Metastatic disease would require a therapeutic strategy tailored to the molecular profile in order to improve the currently disappointing results.

Keywords: Primary squamous cell carcinoma; parotid gland; parotidectomy; salivary gland neoplasms; sialoadenectomy; submandibular gland.

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Conflict of interest statement

Conflict of interest: The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: PAOLO MARCHETTI (PM) has/had a consultant/advisory role for BMS, RocheGenentech, MSD, Novartis, Amgen, Merck Serono, Pierre Fabre, Incyte. The other authors declare they have no competing interests.

Figures

Figure 1.
Figure 1.
MRI images of a 35-year-old patient with squamous cell carcinoma of the right parotid gland (Case 2). Axial T2-weighted image shows ill-defined lesion involving superficial lobe of the right parotid (a). The lesion is inseparable from anterior aspect of sternocleidomastoid muscle (a). Coronal T2 weighted image shows enlarged ipsilateral lymph nodes (b). MRI images of a 75-year-old patient with squamous cell carcinoma of the right submandibular gland (Case 10). Axial T2-weighted image shows an ill-defined mass with diffuse invasive growth involving right submandibular space (c). The lesion is inseparable from ioglossus muscle and ipsilateral parotid gland (c). Coronal T2 fat-sat weighted image shows enlarged ipsilateral lymph nodes (d).
Figure 2.
Figure 2.
Primary squamous carcinoma of the parotid gland (Case 1). Poorly differentiated (G3) squamous carcinoma infiltrating the serous salivary gland tissue (a. Hematoxylin eosin stain). The neoplastic cells were positive to the immunohistochemical stains for CK AE1/AE3 (b) and p63 (c). The tumor proliferative index evaluated by Ki-67 was 70% (d) original magnification 10X.
See this image and copyright information in PMC

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