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. 2020 May 8;8(3):89-95.
doi: 10.4103/JMAU.JMAU_64_19. eCollection 2020 Jul-Sep.

Changing Frequency of Glomerular Diseases in Western Saudi Arabia: A 26-Year Experience

Sawsan Mohammad Jalalah  1
Affiliations

Changing Frequency of Glomerular Diseases in Western Saudi Arabia: A 26-Year Experience

Sawsan Mohammad Jalalah. J Microsc Ultrastruct. .

Abstract

Introduction: The frequency of glomerulonephritis (GN) is reported to be changing in the world over the past four decades. Few studies arise from the western region of Saudi Arabia.

Aims: The aim of this study was to address the frequency of primary GN (1ry GN) and secondary GN (2ry GN) over a period of 26 years in the western region of Saudi Arabia and compare to previous data from other regions of the country.

Subjects and methods: The records of adult renal biopsies, 448 1ry GN and 263 2ry GN, are analyzed. Frequencies of GN subtypes are compared for period 1 (1988-19999) and period 2 (2000-2013).

Results: Postinfectious GN (PIGN) and minimal change disease (MCD) show significant changes (P ≤ 0.05). PIGN increased to 6.5% in period 2 from 0% in period 1. MCD decreased to 5.9% in period 2 from 13.5% in period 1. Membranous GN is the most common 1ry GN for both periods with similar percentages (23.8% and 24.2%, respectively). Focal segmental glomerulosclerosis (FSGSC) is the second in period 2 (23%); immunoglobulin A nephropathy at 9.6% became the third, and MCD is the last place instead of the fourth in period 1. Lupus nephritis is the most common 2ry GN. Pooled data from Saudi studies show FSGSC the most common 1ry GN in both periods.

Conclusions: The western region of Saudi Arabia presents with a different 1ry GN pattern than the rest of the country that is likely attributed to its unique geographical and environmental characteristics.

Keywords: Postinfectious glomerulonephritis; Saudi Arabia; primary glomerulonephritis; secondary glomerulonephritis; western region.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Graph 1
Graph 1
Relationship between 1ry GN subtypes and age
Graph 2
Graph 2
Relationship between 2ry GN subtypes and age
Graph 3
Graph 3
Comparison between the frequencies of 1ry GN subtypes in the current study and pooled data in Saudi Arabia
See this image and copyright information in PMC

References

    1. Hou JH, Zhu HX, Zhou ML, Le WB, Zeng CH, Liang SS, et al. Changes in the spectrum of kidney diseases: An analysis of 40,759 biopsy-proven cases from 2003 to 2014 in China. Kidney Dis (Basel) 2018;4:10–9. - PMC - PubMed
    1. Woo KT, Chan CM, Chin YM, Choong HL, Tan HK, Foo M, et al. Global evolutionary trend of the prevalence of primary glomerulonephritis over the past three decades. Nephron Clin Pract. 2010;116:c337–46. - PubMed
    1. O'Shaughnessy MM, Hogan SL, Poulton CJ, Falk RJ, Singh HK, Nickeleit V, et al. Temporal and demographic trends in glomerular disease epidemiology in the Southeastern United States, 1986-2015. Clin J Am Soc Nephrol. 2017;12:614–23. - PMC - PubMed
    1. Zaza G, Bernich P, Lupo A 'Triveneto' Register of Renal Biopsies (TVRRB) Renal biopsy in chronic kidney disease: Lessons from a large Italian registry. Am J Nephrol. 2013;37:255–63. - PubMed
    1. Dragovic D, Rosenstock JL, Wahl SJ, Panagopoulos G, DeVita MV, Michelis MF. Increasing incidence of focal segmental glomerulosclerosis and an examination of demographic patterns. Clin Nephrol. 2005;63:1–7. - PubMed