Microbiome Biomarkers: One Step Closer in NAFLD Cirrhosis

Tracey G Simon^{1

2

3}, Andrew T Chan^{1

2

3

4

5

6}, Curtis Huttenhower^{5

6

7}

Affiliations

¹ Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA.
² Harvard Medical School, Boston, MA.
³ Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA.
⁴ Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA.
⁵ Broad Institute, Boston, MA.
⁶ Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA.
⁷ Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA.

Comment

Tracey G Simon et al. Hepatology. 2021 May.

. 2021 May;73(5):2063-2066.

doi: 10.1002/hep.31660. Epub 2021 Apr 19.

Tracey G Simon^{1

2

3}, Andrew T Chan^{1

2

3

4

5

6}, Curtis Huttenhower^{5

6

7}

¹ Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA.
² Harvard Medical School, Boston, MA.
³ Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA.
⁴ Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA.
⁵ Broad Institute, Boston, MA.
⁶ Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA.
⁷ Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA.

No abstract available

Comment on

A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis.
Oh TG, Kim SM, Caussy C, Fu T, Guo J, Bassirian S, Singh S, Madamba EV, Bettencourt R, Richards L, Yu RT, Atkins AR, Huan T, Brenner DA, Sirlin CB, Downes M, Evans RM, Loomba R. Oh TG, et al. Cell Metab. 2020 Nov 3;32(5):878-888.e6. doi: 10.1016/j.cmet.2020.06.005. Epub 2020 Jun 30. Cell Metab. 2020. PMID: 32610095 Free PMC article.

1. Boursier J, Diehl AM. Nonalcoholic fatty liver disease and the gut microbiome. Clin Liver Dis 2016;20:263-275. https://doi.org/10.1016/j.cld.2015.10.012.
1. Loomba R, Seguritan V, Li W, Long T, Klitgord N, Bhatt A, et al. Gut microbiome-based metagenomic signature for non-invasive detection of advanced fibrosis in human nonalcoholic fatty liver disease. Cell Metab 2017;25:1054-1062.e5. https://doi.org/10.1016/j.cmet.2017.04.001.
1. Duvallet C, Gibbons SM, Gurry T, Irizarry RA, Alm EJ. Meta-analysis of gut microbiome studies identifies disease-specific and shared responses. Nat Commun 2017;8:1784. https://doi.org/10.1038/s41467-017-01973-8.
1. Oh TG, Kim SM, Caussy C, Fu T, Guo J, Bassirian S, et al. A universal gut-microbiome-derived signature predicts cirrhosis. Cell Metab 2020;32:878-888.e6. https://doi.org/10.1016/j.cmet.2020.06.005.
1. Pasolli E, Truong DT, Malik F, Waldron L, Segata N. Machine Learning meta-analysis of large metagenomic datasets: tools and biological insights. PLoS Comput Biol 2016;12:e1004977. https://doi.org/10.1371/journal.pcbi.1004977.