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Review
. 2021 Mar;34(2):280-287.
doi: 10.1111/pcmr.12950. Epub 2021 Jan 8.

Making a melanoma: Molecular and cellular changes underlying melanoma initiation

Revati Darp  1   2 , Craig Ceol  1   2
Affiliations
Review

Making a melanoma: Molecular and cellular changes underlying melanoma initiation

Revati Darp et al. Pigment Cell Melanoma Res. 2021 Mar.

Abstract

Melanoma arises from the melanocyte lineage and is the most aggressive and lethal form of skin cancer. There are several genetic, genomic, and cellular changes associated with melanoma initiation. Here, we discuss these alterations and the melanoma cells of origin in which they are proposed to promote melanomagenesis.

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References

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