The global impact of the COVID-19 pandemic on the management and course of chronic urticaria

Emek Kocatürk¹, Andaç Salman², Ivan Cherrez-Ojeda³, Paulo Ricardo Criado^{4

5

6}, Jonny Peter⁷, Elif Comert-Ozer², Mohamed Abuzakouk⁸, Rosana Câmara Agondi⁹, Mona Al-Ahmad¹⁰, Sabine Altrichter¹¹, Rand Arnaout¹², Luisa Karla Arruda¹³, Riccardo Asero¹⁴, Andrea Bauer¹⁵, Moshe Ben-Shoshan¹⁶, Jonathan A Bernstein¹⁷, Mojca Bizjak¹⁸, Isabelle Boccon-Gibod¹⁹, Hanna Bonnekoh^{20

21}, Laurence Bouillet¹⁹, Zenon Brzoza²², Paula Busse²³, Regis A Campos^{24

25}, Emily Carne²⁶, Niall Conlon²⁷, Roberta F Criado²⁸, Eduardo M de Souza Lima²⁹, Semra Demir³⁰, Joachim Dissemond³¹, Sibel Doğan Günaydın³², Irina Dorofeeva³³, Luis Felipe Ensina³⁴, Ragıp Ertaş³⁵, Silvia Mariel Ferrucci³⁶, Ignasi Figueras-Nart³⁷, Daria Fomina^{38

39}, Sylvie M Franken⁴⁰, Atsushi Fukunaga⁴¹, Ana M Giménez-Arnau⁴², Kiran Godse⁴³, Margarida Gonçalo⁴⁴, Maia Gotua⁴⁵, Clive Grattan⁴⁶, Carole Guillet⁴⁷, Naoko Inomata⁴⁸, Thilo Jakob⁴⁹, Gul Karakaya⁵⁰, Alicja Kasperska-Zając⁵¹, Constance H Katelaris⁵², Mitja Košnik¹⁸, Dorota Krasowska⁵³, Kanokvalai Kulthanan⁵⁴, M Sendhil Kumaran⁵⁵, Claudia Lang⁴⁷, José Ignacio Larco-Sousa⁵⁶, Elisavet Lazaridou⁵⁷, Tabi Anika Leslie⁵⁸, Undine Lippert⁵⁹, Oscar Calderón Llosa⁶⁰, Michael Makris⁶¹, Alexander Marsland⁶², Iris V Medina⁶³, Raisa Meshkova⁶⁴, Esther Bastos Palitot⁶⁵, Claudio A S Parisi⁶⁶, Julia Pickert⁶⁷, German D Ramon⁶⁸, Mónica Rodríguez-Gonzalez⁶⁹, Nelson Rosario⁷⁰, Michael Rudenko⁷¹, Krzysztof Rutkowski⁷², Jorge Sánchez⁷³, Sibylle Schliemann⁷⁴, Bulent Enis Sekerel⁷⁵, Faradiba S Serpa⁷⁶, Esther Serra-Baldrich⁷⁷, Zhiqiang Song⁷⁸, Angèle Soria⁷⁹, Maria Staevska⁸⁰, Petra Staubach⁸¹, Anna Tagka⁸², Shunsuke Takahagi⁸³, Simon Francis Thomsen⁸⁴, Regina Treudler⁸⁵, Zahava Vadasz⁸⁶, Solange Oliveira Rodrigues Valle⁸⁷, Martijn B A Van Doorn⁸⁸, Christian Vestergaard⁸⁹, Nicola Wagner⁹⁰, Dahu Wang⁹¹, Liangchun Wang⁹², Bettina Wedi⁹³, Paraskevi Xepapadaki⁹⁴, Esra Yücel⁹⁵, Anna Zalewska-Janowska⁹⁶, Zuotao Zhao⁹⁷, Torsten Zuberbier²¹, Marcus Maurer⁹⁸

Affiliations

¹ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, Koç University School of Medicine, Istanbul, Turkey.
² Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, Marmara University School of Medicine, Istanbul, Turkey.
³ Urticaria Center of Reference and Excellence (UCARE), School of Medicine, Universidad de Especialidades Espíritu Santo, Samborondón, Ecuador and RespiraLab, Research, Guayaquil, Ecuador.
⁴ Urticaria Center of Reference and Excellence (UCARE), Faculdade de Medicina do ABC, Santo André, Brazil.
⁵ Alergoskin Alergia e Dermatologia SS ltda, Santo André, Brazil.
⁶ UCARE Center, São Paulo, Brazil.
⁷ Urticaria Center of Reference and Excellence (UCARE), Division of Allergy and Clinical Immunology, Department of Medicine, University of Cape Town, Cape Town, 7925, South Africa.
⁸ Urticaria Center of Reference and Excellence (UCARE), Cleveland Clinic Abu Dhabi, UAE.
⁹ Urticaria Center of Reference and Excellence (UCARE), University of São Paulo, São Paulo, Brazil.
¹⁰ Urticaria Center of Reference and Excellence (UCARE), Microbiology Department, Faculty of Medicine, Kuwait University, Safat, Kuwait.
¹¹ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Berlin, Germany.
¹² Urticaria Center of Reference and Excellence (UCARE), King Faisal Specialist Hospital & Research Center, Al Faisal University, Riyadh, Saudi Arabia.
¹³ Urticaria Center of Reference and Excellence (UCARE), Preto Medical School, University of São Paulo, São Paulo, Brazil.
¹⁴ Urticaria Center of Reference and Excellence (UCARE), Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Italy.
¹⁵ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, University Allergy Center, University Hospital Carl Gustav Carus, Technical University, Dresden, Germany.
¹⁶ Urticaria Center of Reference and Excellence (UCARE), Division of Allergy, Immunology and Dermatology, Department of Pediatrics, McGill University Health Center, Montreal, QC, Canada.
¹⁷ Urticaria Center of Reference and Excellence (UCARE), University of Cincinnati College of Medicine, Division of Immunology, Rheumatology and Allergy, Cincinnati, USA.
¹⁸ Urticaria Center of Reference and Excellence (UCARE), Division of Allergy, University Clinic of Respiratory and Allergic Diseases Golnik, Golnik, Slovenia.
¹⁹ Urticaria Center of Reference and Excellence (UCARE), Clinical Immunology/Internal Medicine Department, National Reference Center for Angioedema, Grenoble University Hospital, Grenoble, France.
²⁰ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology and Allergy, Allergie-Centrum-Charité, Charité - Universitätsmedizin Berlin, Berlin, Germany.
²¹ Autoinflammation Reference Center Charité (ARC2), Charité - Universitätsmedizin Berlin, Berlin, Germany.
²² Urticaria Center of Reference and Excellence (UCARE), Department of Internal Medicine with Division of Allergology, Institute of Medical Sciences, University of Opole, Opole, Poland.
²³ Urticaria Center of Reference and Excellence (UCARE), Division of Clinical Immunology and Allergy, Icahn School at Mount Sinai, New York, NY, USA.
²⁴ Urticaria Center of Reference and Excellence (UCARE), Universidade Federal da Bahia, Salvador, Brazil.
²⁵ Serviço de Imunologia, Hospital das Clínicas Professor Edgard Santos, Salvador, Brazil.
²⁶ Urticaria Center of Reference and Excellence (UCARE), University Hospital of Wales, Cardiff, UK.
²⁷ Urticaria Center of Reference and Excellence (UCARE), Department of Immunology, St James's Hospital and Trinity College, Dublin, Ireland.
²⁸ Urticaria Center of Reference and Excellence (UCARE), Faculdade de Medicina do ABC (FMABC), Santo André, Brazil.
²⁹ Urticaria Center of Reference and Excellence, (UCARE), Faculdade de Ciências, Médicas e da Saúde de Juiz de Fora (SUPREMA), Hospital Maternidade Therezinha de Jesus, Minas Gerais, Brazil.
³⁰ Urticaria Center of Reference and Excellence (UCARE), Division of Allergy, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
³¹ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, Venereology and Allergology, University of Essen, Essen, Germany.
³² Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology and Venereology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
³³ Urticaria Center of Reference and Excellence (UCARE), Department of Allergy and Immunotherapy, Institute of Immunology, FMBA of Russia, Moscow, Russia.
³⁴ Urticaria Center of Reference and Excellence (UCARE), Division of Allergy, Clinical Immunology and Rheumatology, Department of Pediatrics, Federal University of São Paulo, São Paulo, Brazil.
³⁵ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, Kayseri City Education and Research Hospital, Kayseri, Turkey.
³⁶ Urticaria Center of Reference and Excellence (UCARE), Ambulatorio di Dermatologia Allergologica e Professionale, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.
³⁷ Urticaria Center of Reference and Excellence (UCARE), The Dermatology Department of the Hospital de Bellvitge, Universitat de Barcelona, Barcelona, Spain.
³⁸ Urticaria Center of Reference and Excellence (UCARE), Center of Allergy and Immunology, Moscow Ministry of Healthcare, Moscow, Russia.
³⁹ Department of Allergology and Clinical Immunology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
⁴⁰ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, Amsterdam UMC, Amsterdam, The Netherlands.
⁴¹ Urticaria Center of Reference and Excellence (UCARE), Division of Dermatology, Kobe University, Graduate School of Medicine, Kobe, Japan.
⁴² Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, Hospital del Mar, IMIM, Universitat Autònoma, Barcelona, Spain.
⁴³ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, D Y. Patil University School of Medicine, Mumbai, India.
⁴⁴ Urticaria Center of Reference and Excellence (UCARE), Centro Hospitalar Universitário Coimbra and Faculty of Medicine, University of Coimbra, Clinica de Dermatologia, Coimbra, Portugal.
⁴⁵ Urticaria Center of Reference and Excellence (UCARE, Center of Allergy and Immunology, Tbilsi, Georgia.
⁴⁶ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, Guys & St Thomas' Hospital, London, UK.
⁴⁷ Urticaria Center of Reference and Excellence (UCARE), Allergy Unit, Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland.
⁴⁸ Urticaria Center of Reference and Excellence (UCARE), Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
⁴⁹ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology and Allergy, University Medical Center Giessen (UKGM, Justus-Liebig-University Giessen, Giessen, Germany.
⁵⁰ Urticaria Center of Reference and Excellence (UCARE), School of Medicine, Department of Chest Diseases, Adult Allergy Unit, Hacettepe University, Sihhiye Ankara, Turkey.
⁵¹ Urticaria Center of Reference and Excellence (UCARE), European Center for Diagnosis and Treatment of Urticaria, Medical University of Silesia, Zabrze, Poland.
⁵² Urticaria Center of Reference and Excellence (UCARE), Immunology & Allergy Unit, Department of Medicine, Campbelltown Hospital, Campbelltown, NSW, Australia.
⁵³ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, Lublin, Poland.
⁵⁴ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
⁵⁵ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
⁵⁶ Urticaria Center of Reference and Excellence (UCARE), Clinica San Felipe, Lima, Peru.
⁵⁷ Urticaria Center of Reference and Excellence (UCARE), Second department of Dermatology and Venereology, Aristotle University of Thessaloniki, General Hospital Papageorgiou, Thessaloniki, Greece.
⁵⁸ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, Royal Free Hospital, London, UK.
⁵⁹ Urticaria Center of Reference and Excellence (UCARE, Department of Dermatology, Medical Center of University Goettingen, Venerology und Allergology, Goettingen, Germany.
⁶⁰ Urticaria Center of Reference and Excellence (UCARE), Department of Allergy, SANNA el Golf, San Isidro, Lima.
⁶¹ Urticaria Center of Reference and Excellence (UCARE), Second Department of Dermatology and Venereology, National and Kapodistrian University of Athens, University General Hospital "Attikon", Athens, Greece.
⁶² Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, The Urticaria Clinic, Salford Royal Foundation Trust, University of Manchester, Manchester, UK.
⁶³ Urticaria Center of Reference and Excellence (UCARE), Allergy and Clinical Immunology Department, Centro Médico Vitae, de Julio, Argentina.
⁶⁴ Urticaria Center of Reference and Excellence (UCARE), Department of Clinical Immunology and Allergology, Smolensk State Medical University, Smolensk, Russia.
⁶⁵ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, Hospital Universitário Lauro Wanderley, João Pessoa, PB, Brazil.
⁶⁶ Urticaria Center of Reference and Excellence (UCARE), Adults and Pediatrics Allergy Unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
⁶⁷ Urticaria Center of Reference and Excellence (UCARE), Clinical & Experimental Allergology, Department of Dermatology and Allergology, Philipps University Marburg, Marburg, Germany.
⁶⁸ Urticaria Center of Reference and Excellence (UCARE), Instituto de Alergia e Inmunologia del Sur, Buenos Aires, Argentina.
⁶⁹ Urticaria Center of Reference and Excellence (UCARE), Department of Allergy, Hospital Español de México, Mexico City, Mexico.
⁷⁰ Urticaria Center of Reference and Excellence (UCARE), Federal University of Parana, Rua General Carneiro, Curitiba, Brazil.
⁷¹ Urticaria Center of Reference and Excellence (UCARE), London Allergy and Immunology Centre, London, UK.
⁷² Urticaria Center of Reference and Excellence (UCARE), Department of Allergy, Guy's and St Thomas' Hospital NHS Foundation Trust, London, UK.
⁷³ Urticaria Center of Reference and Excellence (UCARE), Department of Pediatrics, Graduate Program on Allergology, University of Antioquia, Medellín, Colombia.
⁷⁴ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, University Hospital Jena, Germany.
⁷⁵ Urticaria Center of Reference and Excellence (UCARE), Department of Pediatric Allergy, Hacettepe University Faculty of Medicine, Ankara, Turkey.
⁷⁶ Urticaria Center of Reference and Excellence (UCARE), Hospital Santa Casa de Misericórdia de Vitória, Espírito Santo, Brazil.
⁷⁷ Urticaria Center of Reference and Excellence (UCARE), Dermatology Department, Hospital Sant Pau, Barcelona, Spain.
⁷⁸ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, Southwest Hospital, Army Medical University, Chongqing, China.
⁷⁹ Urticaria Center of Reference and Excellence (UCARE), Service de Dermatologie et Allergologie, Hopital Tenon, APHP, Université, Paris, Sorbonne, France.
⁸⁰ Urticaria Center of Reference and Excellence (UCARE), Department of Allergy, Sofia Medical University, Sofia, Bulgaria.
⁸¹ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, University Medical Center, Mainz, Germany.
⁸² Urticaria Center of Reference and Excellence (UCARE), First Department of Dermatology and Venereology, National and Kapodistrian University of Athens, "A. Syggros" Hospital, Referral Center of Occupational Dermatological Diseases, Athens, Greece.
⁸³ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
⁸⁴ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark.
⁸⁵ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, Venerology and Allergology and Leipzig Interdisciplinary Center of Allergology Comprehensive Allergy Center, UMC Leipzig, Leipzig, Germany.
⁸⁶ Urticaria Center of Reference and Excellence (UCARE), Division of Allergy and Clinical Immunology, Bnai-Zion Medical Center, Technion Faculty of Medicine, Haifa, Israel.
⁸⁷ Urticaria Center of Reference and Excellence (UCARE), Federal University of Rio de Janeiro, Department of Internal Medicine, Immunology Service, Rio de Janeiro, Brazil.
⁸⁸ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, Erasmus MC, Rotterdam, The Netherlands.
⁸⁹ Urticaria Center of Reference and Excellence (UCARE), Aarhus University Hospital, Aarhus, Denmark.
⁹⁰ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, University of Erlangen, Erlangen, Germany.
⁹¹ Urticaria Center of Reference and Excellence (UCARE), Dermatovenerological Department, The Second Hospital of HeBei Medical University, Shijiazhuang, HeBei Province, China.
⁹² Urticaria Center of Reference and Excellence (UCARE, Dermatology Department of Sun Yat-sen Memorial Hospital, Guangzhou, China.
⁹³ Urticaria Center of Reference and Excellence (UCARE, Department of Dermatology and Allergology, Hannover Medical School, Allergology Division, Hannover, Germany.
⁹⁴ Urticaria Center of Reference and Excellence (UCARE), Department of Allergy, 2nd Pediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece.
⁹⁵ Urticaria Center of Reference and Excellence (UCARE), Department of Pediatric Allergy and Immunology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
⁹⁶ Urticaria Center of Reference and Excellence (UCARE), Chair of Clinical Immunology and Rheumatology, Department of Psychodermatology, Medical University of Lodz, Lodz, Poland.
⁹⁷ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology and Venerology, Peking University First Hospital, Beijing Key Laboratory of molecular Diagnosis on Dermatoses and National Clinical Research Center for Skin and Immune Diseases, Beijing, China.
⁹⁸ Urticaria Center of Reference and Excellence (UCARE), Dermatological Allergology, Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité - Universitätsmedizin, Berlin, Germany.

PMID: 33284457
DOI: 10.1111/all.14687

Multicenter Study

The global impact of the COVID-19 pandemic on the management and course of chronic urticaria

Emek Kocatürk et al. Allergy. 2021 Mar.

. 2021 Mar;76(3):816-830.

doi: 10.1111/all.14687. Epub 2020 Dec 29.

Authors

Affiliations

¹ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, Koç University School of Medicine, Istanbul, Turkey.
² Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, Marmara University School of Medicine, Istanbul, Turkey.
³ Urticaria Center of Reference and Excellence (UCARE), School of Medicine, Universidad de Especialidades Espíritu Santo, Samborondón, Ecuador and RespiraLab, Research, Guayaquil, Ecuador.
⁴ Urticaria Center of Reference and Excellence (UCARE), Faculdade de Medicina do ABC, Santo André, Brazil.
⁵ Alergoskin Alergia e Dermatologia SS ltda, Santo André, Brazil.
⁶ UCARE Center, São Paulo, Brazil.
⁷ Urticaria Center of Reference and Excellence (UCARE), Division of Allergy and Clinical Immunology, Department of Medicine, University of Cape Town, Cape Town, 7925, South Africa.
⁸ Urticaria Center of Reference and Excellence (UCARE), Cleveland Clinic Abu Dhabi, UAE.
⁹ Urticaria Center of Reference and Excellence (UCARE), University of São Paulo, São Paulo, Brazil.
¹⁰ Urticaria Center of Reference and Excellence (UCARE), Microbiology Department, Faculty of Medicine, Kuwait University, Safat, Kuwait.
¹¹ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Berlin, Germany.
¹² Urticaria Center of Reference and Excellence (UCARE), King Faisal Specialist Hospital & Research Center, Al Faisal University, Riyadh, Saudi Arabia.
¹³ Urticaria Center of Reference and Excellence (UCARE), Preto Medical School, University of São Paulo, São Paulo, Brazil.
¹⁴ Urticaria Center of Reference and Excellence (UCARE), Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Italy.
¹⁵ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, University Allergy Center, University Hospital Carl Gustav Carus, Technical University, Dresden, Germany.
¹⁶ Urticaria Center of Reference and Excellence (UCARE), Division of Allergy, Immunology and Dermatology, Department of Pediatrics, McGill University Health Center, Montreal, QC, Canada.
¹⁷ Urticaria Center of Reference and Excellence (UCARE), University of Cincinnati College of Medicine, Division of Immunology, Rheumatology and Allergy, Cincinnati, USA.
¹⁸ Urticaria Center of Reference and Excellence (UCARE), Division of Allergy, University Clinic of Respiratory and Allergic Diseases Golnik, Golnik, Slovenia.
¹⁹ Urticaria Center of Reference and Excellence (UCARE), Clinical Immunology/Internal Medicine Department, National Reference Center for Angioedema, Grenoble University Hospital, Grenoble, France.
²⁰ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology and Allergy, Allergie-Centrum-Charité, Charité - Universitätsmedizin Berlin, Berlin, Germany.
²¹ Autoinflammation Reference Center Charité (ARC2), Charité - Universitätsmedizin Berlin, Berlin, Germany.
²² Urticaria Center of Reference and Excellence (UCARE), Department of Internal Medicine with Division of Allergology, Institute of Medical Sciences, University of Opole, Opole, Poland.
²³ Urticaria Center of Reference and Excellence (UCARE), Division of Clinical Immunology and Allergy, Icahn School at Mount Sinai, New York, NY, USA.
²⁴ Urticaria Center of Reference and Excellence (UCARE), Universidade Federal da Bahia, Salvador, Brazil.
²⁵ Serviço de Imunologia, Hospital das Clínicas Professor Edgard Santos, Salvador, Brazil.
²⁶ Urticaria Center of Reference and Excellence (UCARE), University Hospital of Wales, Cardiff, UK.
²⁷ Urticaria Center of Reference and Excellence (UCARE), Department of Immunology, St James's Hospital and Trinity College, Dublin, Ireland.
²⁸ Urticaria Center of Reference and Excellence (UCARE), Faculdade de Medicina do ABC (FMABC), Santo André, Brazil.
²⁹ Urticaria Center of Reference and Excellence, (UCARE), Faculdade de Ciências, Médicas e da Saúde de Juiz de Fora (SUPREMA), Hospital Maternidade Therezinha de Jesus, Minas Gerais, Brazil.
³⁰ Urticaria Center of Reference and Excellence (UCARE), Division of Allergy, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
³¹ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, Venereology and Allergology, University of Essen, Essen, Germany.
³² Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology and Venereology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
³³ Urticaria Center of Reference and Excellence (UCARE), Department of Allergy and Immunotherapy, Institute of Immunology, FMBA of Russia, Moscow, Russia.
³⁴ Urticaria Center of Reference and Excellence (UCARE), Division of Allergy, Clinical Immunology and Rheumatology, Department of Pediatrics, Federal University of São Paulo, São Paulo, Brazil.
³⁵ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, Kayseri City Education and Research Hospital, Kayseri, Turkey.
³⁶ Urticaria Center of Reference and Excellence (UCARE), Ambulatorio di Dermatologia Allergologica e Professionale, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.
³⁷ Urticaria Center of Reference and Excellence (UCARE), The Dermatology Department of the Hospital de Bellvitge, Universitat de Barcelona, Barcelona, Spain.
³⁸ Urticaria Center of Reference and Excellence (UCARE), Center of Allergy and Immunology, Moscow Ministry of Healthcare, Moscow, Russia.
³⁹ Department of Allergology and Clinical Immunology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
⁴⁰ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, Amsterdam UMC, Amsterdam, The Netherlands.
⁴¹ Urticaria Center of Reference and Excellence (UCARE), Division of Dermatology, Kobe University, Graduate School of Medicine, Kobe, Japan.
⁴² Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, Hospital del Mar, IMIM, Universitat Autònoma, Barcelona, Spain.
⁴³ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, D Y. Patil University School of Medicine, Mumbai, India.
⁴⁴ Urticaria Center of Reference and Excellence (UCARE), Centro Hospitalar Universitário Coimbra and Faculty of Medicine, University of Coimbra, Clinica de Dermatologia, Coimbra, Portugal.
⁴⁵ Urticaria Center of Reference and Excellence (UCARE, Center of Allergy and Immunology, Tbilsi, Georgia.
⁴⁶ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, Guys & St Thomas' Hospital, London, UK.
⁴⁷ Urticaria Center of Reference and Excellence (UCARE), Allergy Unit, Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland.
⁴⁸ Urticaria Center of Reference and Excellence (UCARE), Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
⁴⁹ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology and Allergy, University Medical Center Giessen (UKGM, Justus-Liebig-University Giessen, Giessen, Germany.
⁵⁰ Urticaria Center of Reference and Excellence (UCARE), School of Medicine, Department of Chest Diseases, Adult Allergy Unit, Hacettepe University, Sihhiye Ankara, Turkey.
⁵¹ Urticaria Center of Reference and Excellence (UCARE), European Center for Diagnosis and Treatment of Urticaria, Medical University of Silesia, Zabrze, Poland.
⁵² Urticaria Center of Reference and Excellence (UCARE), Immunology & Allergy Unit, Department of Medicine, Campbelltown Hospital, Campbelltown, NSW, Australia.
⁵³ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, Lublin, Poland.
⁵⁴ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
⁵⁵ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
⁵⁶ Urticaria Center of Reference and Excellence (UCARE), Clinica San Felipe, Lima, Peru.
⁵⁷ Urticaria Center of Reference and Excellence (UCARE), Second department of Dermatology and Venereology, Aristotle University of Thessaloniki, General Hospital Papageorgiou, Thessaloniki, Greece.
⁵⁸ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, Royal Free Hospital, London, UK.
⁵⁹ Urticaria Center of Reference and Excellence (UCARE, Department of Dermatology, Medical Center of University Goettingen, Venerology und Allergology, Goettingen, Germany.
⁶⁰ Urticaria Center of Reference and Excellence (UCARE), Department of Allergy, SANNA el Golf, San Isidro, Lima.
⁶¹ Urticaria Center of Reference and Excellence (UCARE), Second Department of Dermatology and Venereology, National and Kapodistrian University of Athens, University General Hospital "Attikon", Athens, Greece.
⁶² Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, The Urticaria Clinic, Salford Royal Foundation Trust, University of Manchester, Manchester, UK.
⁶³ Urticaria Center of Reference and Excellence (UCARE), Allergy and Clinical Immunology Department, Centro Médico Vitae, de Julio, Argentina.
⁶⁴ Urticaria Center of Reference and Excellence (UCARE), Department of Clinical Immunology and Allergology, Smolensk State Medical University, Smolensk, Russia.
⁶⁵ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, Hospital Universitário Lauro Wanderley, João Pessoa, PB, Brazil.
⁶⁶ Urticaria Center of Reference and Excellence (UCARE), Adults and Pediatrics Allergy Unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
⁶⁷ Urticaria Center of Reference and Excellence (UCARE), Clinical & Experimental Allergology, Department of Dermatology and Allergology, Philipps University Marburg, Marburg, Germany.
⁶⁸ Urticaria Center of Reference and Excellence (UCARE), Instituto de Alergia e Inmunologia del Sur, Buenos Aires, Argentina.
⁶⁹ Urticaria Center of Reference and Excellence (UCARE), Department of Allergy, Hospital Español de México, Mexico City, Mexico.
⁷⁰ Urticaria Center of Reference and Excellence (UCARE), Federal University of Parana, Rua General Carneiro, Curitiba, Brazil.
⁷¹ Urticaria Center of Reference and Excellence (UCARE), London Allergy and Immunology Centre, London, UK.
⁷² Urticaria Center of Reference and Excellence (UCARE), Department of Allergy, Guy's and St Thomas' Hospital NHS Foundation Trust, London, UK.
⁷³ Urticaria Center of Reference and Excellence (UCARE), Department of Pediatrics, Graduate Program on Allergology, University of Antioquia, Medellín, Colombia.
⁷⁴ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, University Hospital Jena, Germany.
⁷⁵ Urticaria Center of Reference and Excellence (UCARE), Department of Pediatric Allergy, Hacettepe University Faculty of Medicine, Ankara, Turkey.
⁷⁶ Urticaria Center of Reference and Excellence (UCARE), Hospital Santa Casa de Misericórdia de Vitória, Espírito Santo, Brazil.
⁷⁷ Urticaria Center of Reference and Excellence (UCARE), Dermatology Department, Hospital Sant Pau, Barcelona, Spain.
⁷⁸ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, Southwest Hospital, Army Medical University, Chongqing, China.
⁷⁹ Urticaria Center of Reference and Excellence (UCARE), Service de Dermatologie et Allergologie, Hopital Tenon, APHP, Université, Paris, Sorbonne, France.
⁸⁰ Urticaria Center of Reference and Excellence (UCARE), Department of Allergy, Sofia Medical University, Sofia, Bulgaria.
⁸¹ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, University Medical Center, Mainz, Germany.
⁸² Urticaria Center of Reference and Excellence (UCARE), First Department of Dermatology and Venereology, National and Kapodistrian University of Athens, "A. Syggros" Hospital, Referral Center of Occupational Dermatological Diseases, Athens, Greece.
⁸³ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
⁸⁴ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark.
⁸⁵ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, Venerology and Allergology and Leipzig Interdisciplinary Center of Allergology Comprehensive Allergy Center, UMC Leipzig, Leipzig, Germany.
⁸⁶ Urticaria Center of Reference and Excellence (UCARE), Division of Allergy and Clinical Immunology, Bnai-Zion Medical Center, Technion Faculty of Medicine, Haifa, Israel.
⁸⁷ Urticaria Center of Reference and Excellence (UCARE), Federal University of Rio de Janeiro, Department of Internal Medicine, Immunology Service, Rio de Janeiro, Brazil.
⁸⁸ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, Erasmus MC, Rotterdam, The Netherlands.
⁸⁹ Urticaria Center of Reference and Excellence (UCARE), Aarhus University Hospital, Aarhus, Denmark.
⁹⁰ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology, University of Erlangen, Erlangen, Germany.
⁹¹ Urticaria Center of Reference and Excellence (UCARE), Dermatovenerological Department, The Second Hospital of HeBei Medical University, Shijiazhuang, HeBei Province, China.
⁹² Urticaria Center of Reference and Excellence (UCARE, Dermatology Department of Sun Yat-sen Memorial Hospital, Guangzhou, China.
⁹³ Urticaria Center of Reference and Excellence (UCARE, Department of Dermatology and Allergology, Hannover Medical School, Allergology Division, Hannover, Germany.
⁹⁴ Urticaria Center of Reference and Excellence (UCARE), Department of Allergy, 2nd Pediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece.
⁹⁵ Urticaria Center of Reference and Excellence (UCARE), Department of Pediatric Allergy and Immunology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
⁹⁶ Urticaria Center of Reference and Excellence (UCARE), Chair of Clinical Immunology and Rheumatology, Department of Psychodermatology, Medical University of Lodz, Lodz, Poland.
⁹⁷ Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology and Venerology, Peking University First Hospital, Beijing Key Laboratory of molecular Diagnosis on Dermatoses and National Clinical Research Center for Skin and Immune Diseases, Beijing, China.
⁹⁸ Urticaria Center of Reference and Excellence (UCARE), Dermatological Allergology, Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité - Universitätsmedizin, Berlin, Germany.

PMID: 33284457
DOI: 10.1111/all.14687

Abstract

Introduction: The COVID-19 pandemic dramatically disrupts health care around the globe. The impact of the pandemic on chronic urticaria (CU) and its management are largely unknown.

Aim: To understand how CU patients are affected by the COVID-19 pandemic; how specialists alter CU patient management; and the course of CU in patients with COVID-19.

Materials and methods: Our cross-sectional, international, questionnaire-based, multicenter UCARE COVID-CU study assessed the impact of the pandemic on patient consultations, remote treatment, changes in medications, and clinical consequences.

Results: The COVID-19 pandemic severely impairs CU patient care, with less than 50% of the weekly numbers of patients treated as compared to before the pandemic. Reduced patient referrals and clinic hours were the major reasons. Almost half of responding UCARE physicians were involved in COVID-19 patient care, which negatively impacted on the care of urticaria patients. The rate of face-to-face consultations decreased by 62%, from 90% to less than half, whereas the rate of remote consultations increased by more than 600%, from one in 10 to more than two thirds. Cyclosporine and systemic corticosteroids, but not antihistamines or omalizumab, are used less during the pandemic. CU does not affect the course of COVID-19, but COVID-19 results in CU exacerbation in one of three patients, with higher rates in patients with severe COVID-19.

Conclusions: The COVID-19 pandemic brings major changes and challenges for CU patients and their physicians. The long-term consequences of these changes, especially the increased use of remote consultations, require careful evaluation.

Keywords: COVID-19; SARS-CoV-2; UCARE; chronic urticaria; cyclosporine; omalizumab; pandemic; treatment.

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References

REFERENCES

1. Fricke J, Ávila G, Keller T, et al. Prevalence of chronic urticaria in children and adults across the globe: Systematic review with meta-analysis. Allergy 2020;75(2):423-432. https://doi.org/10.1111/all.14037
1. Zuberbier T, Aberer W, Asero R, et al. The EAACI/GA2LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria. Allergy 2018;73(7):1393-1414. https://doi.org/10.1111/all.13397
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The global impact of the COVID-19 pandemic on the management and course of chronic urticaria

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The global impact of the COVID-19 pandemic on the management and course of chronic urticaria

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LinkOut - more resources

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Medical

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