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. 2021 Feb:168:109468.
doi: 10.1016/j.apradiso.2020.109468. Epub 2020 Nov 24.

Automated production of [18F]MK-6240 on CFN-MPS200

Jun Toyohara  1 , Kosuke Nishino  2 , Masanari Sakai  2 , Tetsuro Tago  3 , Takashi Oda  4
Affiliations

Automated production of [18F]MK-6240 on CFN-MPS200

Jun Toyohara et al. Appl Radiat Isot. 2021 Feb.

Abstract

Automated production of [18F]MK-6240 was implemented for the first time in the CFN-MPS200 module. Three consecutive productions of [18F]MK-6240 complied with the product specifications. Formulated [18F]MK-6240 maintained stability, as measured by radio-high-performance liquid chromatography (HPLC), as well as clarity and pH, over a period of 8 h. Our established method can facilitate multi-center trials and widespread use of [18F]MK-6240.

Keywords: Automated production; Fluorine-18; MK-6240; Positron emission tomography; Tau.

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