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Review
. 2020 Dec 3;9(12):1227.
doi: 10.3390/antiox9121227.

Vitamin C and Cardiovascular Disease: An Update

Marco B Morelli  1   2 , Jessica Gambardella  1   2   3   4 , Vanessa Castellanos  1 , Valentina Trimarco  5 , Gaetano Santulli  1   2   3   4
Affiliations
Review

Vitamin C and Cardiovascular Disease: An Update

Marco B Morelli et al. Antioxidants (Basel). .

Abstract

The potential beneficial effects of the antioxidant properties of vitamin C have been investigated in a number of pathological conditions. In this review, we assess both clinical and preclinical studies evaluating the role of vitamin C in cardiac and vascular disorders, including coronary heart disease, heart failure, hypertension, and cerebrovascular diseases. Pitfalls and controversies in investigations on vitamin C and cardiovascular disorders are also discussed.

Keywords: COVID–19; GULO; SVCT; Vitamin C; ascorbic acid; blood pressure; coronavirus; dietary supplements; drug formulations; endothelial dysfunction; heart failure; hypertension; infections; liposomes; oxidative stress; stroke; vascular permeability.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the paper.

Figures

Figure 1
Figure 1
Reduced (left) and oxidized (right) forms of vitamin C.
See this image and copyright information in PMC

References

    1. Kyle: R.A., Shampo M.A. Albert Szent-Gyorgy—Nobel laureate. Mayo Clin. Proc. 2000;75:722. doi: 10.1016/S0025-6196(11)64619-3. - DOI - PubMed
    1. Szent-Gyorgyi A. The Identification of Vitamin C. Science. 1938;87:214–215. doi: 10.1126/science.87.2253.214-a. - DOI - PubMed
    1. Zilva S.S. The Antiscorbutic Fraction of Lemon Juice. I. Biochem. J. 1924;18:182–185. doi: 10.1042/bj0180182. - DOI - PMC - PubMed
    1. Carpenter K.J. The discovery of vitamin C. Ann. Nutr. Metab. 2012;61:259–264. doi: 10.1159/000343121. - DOI - PubMed
    1. De Tullio M.C. Beyond the antioxidant: The double life of vitamin C. Subcell. Biochem. 2012;56:49–65. - PubMed

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