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Case Reports
. 2020 Dec 7;46(1):180.
doi: 10.1186/s13052-020-00947-9.

A neonatal cluster of novel coronavirus disease 2019: clinical management and considerations

Nicole Olivini  1 , Francesca Ippolita Calò Carducci  2 , Veronica Santilli  2 , Maria Antonietta De Ioris  3 , Alessia Scarselli  3 , Dario Alario  4 , Caterina Geremia  3 , Mary Haywood Lombardi  3 , Caterina Marabotto  3 , Rosanna Mariani  3 , Raffaele Edo Papa  3 , Emanuela Peschiaroli  3 , Raffaella Scrocca  3 , Serena Sinibaldi  3 , Andrea Smarrazzo  3 , Pietro Stella  3 , Stefania Bernardi  2 , Sara Chiurchiù  5 , Paola Pansa  5 , Lorenza Romani  5 , Carletti Michaela  6 , Carlo Concato  7 , Domenico Umberto De Rose  8 , Gugliemo Salvatori  8 , Paolo Rossi  2   9 , Alberto Villani  5 , Andrea Dotta  8 , Patrizia D'Argenio  2 , Andrea Campana  3
Affiliations
Case Reports

A neonatal cluster of novel coronavirus disease 2019: clinical management and considerations

Nicole Olivini et al. Ital J Pediatr. .

Abstract

Background: Lately, one of the major clinical and public health issues has been represented by Coronavirus disease of 2019 (COVID-19) during pregnancy and the risk of transmission of the infection from mother to child. Debate on perinatal management and postnatal care is still ongoing, principally questioning the option of the joint management of mother and child after birth and the safety of breastfeeding. According to the available reports, neonatal COVID-19 appears to have a horizontal transmission and seems to be paucisymptomatic or asymptomatic, compared to older age groups. The aim of this work is to describe a cluster of neonatal COVID-19 and discuss our experience, with reference to current evidence on postnatal care and perinatal management.

Methods: This is a retrospective observational case series of five mother-child dyads, who attended the Labor and Delivery Unit of a first-level hospital in Italy, in March 2020. Descriptive statistics for continuous variables consisted of number of observations, mean and the range of the minimum and maximum values.

Results: Five women and four neonates tested positive for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). In one case, the mother-child dyad was separated and the neonate remained negative on two consecutive tests. Two positive neonates developed symptoms, with a predominant involvement of the gastrointestinal tract. Blood tests were unremarkable, except for a single patient who developed mild neutropenia. No complications occurred.

Conclusions: We agree that the decision on whether or not to separate a positive/suspected mother from her child should be made on an individual basis, taking into account the parent's will, clinical condition, hospital logistics and the local epidemiological situation. In conformity with literature, in our study, affected neonates were asymptomatic or paucisymptomatic. Despite these reassuring findings, a few cases of severe presentation in the neonatal population have been reported. Therefore, we agree on encouraging clinicians to monitor the neonates with a suspected or confirmed infection.

Keywords: COVID-19; Infection; Newborns; Pandemic; SARS-CoV-2.

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Conflict of interest statement

The authors declare that they have no competing interests.

References

    1. Helen Davidson. First Covid-19 case happened in November, China government records show - report. The Guardian. [Internet] 2020 Mar 13. Available from: https://www.theguardian.com/world/2020/mar/13/first-covid-19-case-happen.... [Accessed on April 2, 2020].
    1. World Health Organization. Coronavirus disease 2019 (COVID-19) Situation Report – 149. [Internet]. Updated November 10, 2020. Available from: https://www.who.int/publications/m/item/weekly-epidemiological-update%2D.... [Accessed on November 11, 2020].
    1. Ministero della Salute. Fonte: Protezione Civile. Covid-19 - Situazione in Italia. [Internet] Available from: http://opendatadpc.maps.arcgis.com/apps/opsdashboard/index.html#/b0c68bc.... [Accessed on November 08, 2020].
    1. Chen D, Yang H, Cao Y, et al. Expert consensus for managing pregnant women and neonates born to mothers with suspected or confirmed novel coronavirus (COVID-19) infection. Int J Gynaecol Obstet. 2020;149(2):130–136. doi: 10.1002/ijgo.13146. - DOI - PMC - PubMed
    1. The American College of Obstetrics and Gynaecologists (ACOG). Novel Coronavirus 2019 (COVID-19) Practice Advisory. [Internet]. March 2020. Available at: https://www.acog.org/Clinical-Guidance-and-Publications/Practice-Advisor.... [Accessed on April 12, 2020].