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. 2021 Feb;126(2):e72-e75.
doi: 10.1016/j.bja.2020.11.006. Epub 2020 Nov 14.

Potential for personalised application of inhaled nitric oxide in COVID-19 pneumonia

Benjamin Garfield  1 , Charles McFadyen  2 , Charlotte Briar  2 , Caroline Bleakley  2 , Aikaterini Vlachou  2 , Melissa Baldwin  2 , Nick Lees  3 , Susanna Price  1 , Stephane Ledot  2 , Colm McCabe  4 , S John Wort  4 , Brijesh V Patel  5 , Laura C Price  6
Affiliations

Potential for personalised application of inhaled nitric oxide in COVID-19 pneumonia

Benjamin Garfield et al. Br J Anaesth. 2021 Feb.
No abstract available

Keywords: ARDS; COVID-19; inhaled nitric oxide; pulmonary hypertension; right ventricular dysfunction.

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Figures

Fig 1
Fig 1
(a) PaO2/FiO2 (kPa) in the 24 h before and at time points after starting iNO in patients with moderately severe ARDS and Covid-19 infection. There was no significant rebound worsening in the PaO2/FiO2 ratio in the 24 h after stopping iNO. (b) Dead space fraction, defined using Bohr equation with Engelhoff modification, in the 24 h before and at time points after starting iNO in patients with moderately severe ARDS and Covid-19 infection. There was no significant difference between pre stopping and post stopping iNO. Values are average of three measurements at each time point. ∗Denotes a significant difference between this time point and pre-starting iNO. ∗P<0.05; ∗∗P<0.01; ∗∗∗P<0.001. PaO2/FiO2, partial pressure of arterial oxygen/fraction of inspired oxygen; ARDS, acute respiratory distress syndrome; iNO, inhaled nitric oxide. 159×73 mm (300×300 DPI).
See this image and copyright information in PMC

References

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