Flupirtine in the treatment of post-operative pain

Abstract

Flupirtine maleate (referred to throughout this paper as flupirtine) capsules 100 mg and suppositories 150 mg were found to be safe and efficacious in several randomized, controlled, double-blind parallel group clinical trials. 586 patients (40 children) suffering from post-operative pain were treated. Flupirtine was significantly more effective than placebo and as well tolerated. It was as effective and acceptable as pentazocine and dihydrocodeine for the treatment of post-operative pain, but offered advantages in terms of fewer central nervous system side effects. It was at least as effective as the non-narcotics metamizole, paracetamol and naproxen.