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Review
. 2021 Apr;45(4):740-748.
doi: 10.1002/cbin.11516. Epub 2021 Jan 13.

Serological tests for COVID-19: Potential opportunities

Marcarious M Tantuoyir  1   2   3 , Nima Rezaei  1   4   5
Affiliations
Review

Serological tests for COVID-19: Potential opportunities

Marcarious M Tantuoyir et al. Cell Biol Int. 2021 Apr.

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel betacoronavirus, caused a pandemic leading to a standstill of nearly all global activities. There are some controversies on the production of specific immunoglobulin M (IgM) and IgG antibodies after the infection with SARS-CoV-2. This paper seeks to elaborate on the potential application of IgM and IgG antibodies and the viral antigens for the diagnosis and the course of the disease as well as the recurrence of positive nucleic acid tests after discharge.

Keywords: IgG; IgM; SARS-CoV-2; antibody; coronavirus; diagnosis.

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Conflict of interest statement

The authors declare that there are no conflict of interests.

Comment in

References

    1. Bao, L. , Deng, W. , Gao, H. , Xiao, C. , Liu, J. , Xue, J. , Lv, Q. , Liu, J. , Yu, P. , Xu, Y. , Qi, F. , Qu, Y. , Li, F. , Xiang, Z. , Yu, H. , Gong, S. , Liu, M. , Wang, G. , Wang, S. , … Qin, C. (2020). Lack of reinfection in Rhesus macaques infected with SARS‐CoV‐2. BioRxiv. 10.1101/2020.03.13.990226 - DOI - PMC - PubMed
    1. Bastos, M. L. , Tavaziva, G. , Abidi, S. K. , Campbell, J. R. , Haraoui, L. , Johnston, J. C. , Lan, Z. , Law, S. , Maclean, E. , Trajman, A. , Menzies, D. , Benedetti, A. , & Khan, F. A. (2020). Diagnostic accuracy of serological tests for COVID‐19: systematic review and meta‐analysis. BMJ, 370. 10.1136/bmj.m2516 - DOI - PMC - PubMed
    1. Bryan, A. , Pepper, G. , Wener, M. H. , Fink, S. L. , Morishima, C. , Chaudhary, A. , Jerome, K. R. , Mathias, P. C. , & Greninger, A. L. (2020). Performance characteristics of the Abbott Architect SARS‐CoV‐2 IgG assay and seroprevalence in Boise, Idaho. Journal of Clinical Microbiology, 58(8). 10.1128/JCM.00941-20 - DOI - PMC - PubMed
    1. Chen, M. , An, W. , Xia, F. , Yang, P. , Li, K. , Zhou, Q. , Fang, S. , Liao, Y. , Xu, X. , Liu, J. , Liu, S. , Qin, T. , Zhang, J. , Wei, W. , Zhang, Y. , Zhang, G. , & Zhang, M. (2020). Clinical characteristics of re‐hospitalized patients with COVID‐19 in China. Journal of Medical Virology. 10.1002/jmv.26002 - DOI - PMC - PubMed
    1. Du, Z. , Zhu, F. , Guo, F. , Yang, B. , & Wang, T. (2020). Detection of antibodies against SARS‐CoV‐2 in patients with COVID‐19. Journal of Medical Virology, 57, 1–4. 10.1002/jmv.25820 - DOI - PMC - PubMed

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