Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2020 Dec 7;55(5):522-524.
doi: 10.1016/j.devcel.2020.11.015.

A Window into Your Gut: Biologically Inspired Engineering of Mini-gut Tubes In Vitro

Magdalena Kasendra  1 , James M Wells  2
Affiliations
Free article
Comment

A Window into Your Gut: Biologically Inspired Engineering of Mini-gut Tubes In Vitro

Magdalena Kasendra et al. Dev Cell. .
Free article

Abstract

Recently in Nature, using biologically inspired design principles to recapitulate native crypt-villi topography and luminal flow, Nikolaev et al. engineered an intestinal organotypic culture system that is capable of long-term epithelial homeostasis. Mini-gut tubes were used in month-long studies of parasite-host interactions and completely regenerated following injury.

PubMed Disclaimer

Conflict of interest statement

Declaration of Interests J.M.W. holds patents on technology related to gastrointestinal organoids derived from pluripotent stem cells. M.K. holds patents on technology related to systems and methods for growth of intestinal cells in microfluidic devices.

Comment on

Publication types

LinkOut - more resources