Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Dec 6;21(23):9300.
doi: 10.3390/ijms21239300.

Immune Checkpoint Blockade in Advanced Cutaneous Squamous Cell Carcinoma: What Do We Currently Know in 2020?

Anja Wessely  1   2 , Theresa Steeb  1   2 , Ulrike Leiter  3 , Claus Garbe  3 , Carola Berking  1   2 , Markus Vincent Heppt  1   2
Affiliations
Review

Immune Checkpoint Blockade in Advanced Cutaneous Squamous Cell Carcinoma: What Do We Currently Know in 2020?

Anja Wessely et al. Int J Mol Sci. .

Abstract

Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer that predominantly arises in chronically sun-damaged skin. Immunosuppression, genetic disorders such as xeroderma pigmentosum (XP), exposure to certain drugs and environmental noxae have been identified as major risk factors. Surgical removal of cSCC is the therapy of choice and mostly curative in early stages. However, a minority of patients develop locally advanced tumors or distant metastases that are still challenging to treat. Immune checkpoint blockade (ICB) targeting CTLA-4, PD-L1 and PD-1 has tremendously changed the field of oncological therapy and especially the treatment of skin cancers as tumors with a high mutational burden. In this review, we focus on the differences between cSCC and cutaneous melanoma (CM) and their implications on therapy, summarize the current evidence on ICB for the treatment of advanced cSCC and discuss the chances and pitfalls of this therapy option for this cancer entity. Furthermore, we focus on special subgroups of interest such as organ transplant recipients, patients with hematologic malignancies, XP and field cancerization.

Keywords: cemiplimab; cutaneous squamous cell carcinoma; immune checkpoint blockade; pembrolizumab; skin cancer.

PubMed Disclaimer

Conflict of interest statement

C.B. has been member of advisory boards for and/or has received speaker honoraria by Almirall Hermal, Bristol-Myers Squibb, Immunocore, Leo Pharma, Merck, MSD, Novartis, Pierre Fabre, Regeneron, Roche and Sanofi-Aventis. M.V.H. has been a member of advisory boards for Almirall Hermal, Sanofi-Aventis and received speaker honoraria by Galderma. C.G. reports personal fees from Amgen, grants and personal fees from BMS, personal fees from MSD, grants and personal fees from Novartis, personal fees from Philogen, personal fees from Pierre Fabre, grants and personal fees from Roche, grants and personal fees from Sanofi, Jansen outside the submitted work. All other authors report no conflicts of interest.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Lomas A., Leonardi-Bee J., Bath-Hextall F. A systematic review of worldwide incidence of nonmelanoma skin cancer. Br. J. Dermatol. 2012;166:1069–1080. doi: 10.1111/j.1365-2133.2012.10830.x. - DOI - PubMed
    1. Sanchez-Danes A., Blanpain C. Deciphering the cells of origin of squamous cell carcinomas. Nat. Rev. Cancer. 2018;18:549–561. doi: 10.1038/s41568-018-0024-5. - DOI - PMC - PubMed
    1. Criscione V.D., Weinstock M.A., Naylor M.F., Luque C., Eide M.J., Bingham S.F., Department of Veteran Affairs Topical Tretinoin Chemoprevention Trial Group Actinic keratoses: Natural history and risk of malignant transformation in the Veterans Affairs Topical Tretinoin Chemoprevention Trial. Cancer. 2009;115:2523–2530. doi: 10.1002/cncr.24284. - DOI - PubMed
    1. Werner R.N., Sammain A., Erdmann R., Hartmann V., Stockfleth E., Nast A. The natural history of actinic keratosis: A systematic review. Br. J. Dermatol. 2013;169:502–518. doi: 10.1111/bjd.12420. - DOI - PubMed
    1. Cerio R., Dirschka T., Dreno B., Figueras Nart I., Lear J.T., Pellacani G., Peris K., de Casas A.R. Actinic Keratosis, a Chronic, Progressive Disease: Understanding Clinical Gaps to Optimise Patient Management. Acta Derm. Venereol. 2017;97:997–998. doi: 10.2340/00015555-2692. - DOI - PubMed

MeSH terms

Substances