Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Dec 2;48(1):96.
doi: 10.1186/s41182-020-00284-x.

A literature review on the parvovirus B19 infection in sickle cell anemia and β-thalassemia patients

Saber Soltani  1 , Armin Zakeri  2 , Alireza Tabibzadeh  3 , Milad Zandi  1 , Elham Ershadi  1 , Sara Akhavan Rezayat  4 , Sanaz Khaseb  2 , Amir Mohammad Zakeri  5 , Mohammadvala Ashtar Nakhaei  6 , Shervin Afzali  6 , Abbas Farahani  7
Affiliations
Review

A literature review on the parvovirus B19 infection in sickle cell anemia and β-thalassemia patients

Saber Soltani et al. Trop Med Health. .

Abstract

Background: Parvovirus B19 is the causative agent for erythema infectiosum, and also as a potentially life-threatening infectious agent, it is mainly presented in high erythrocyte turnover patients. Sickle cell disease (SCD) is an inherited monogenic hematological disorder resulting from the mutations in the hemoglobin β-chain gene. Thalassemia is a hereditary hematological syndrome that happens in consequence of deficiencies in the production of one or more globin chains. We summarize current knowledge about the prevalence rates of the parvovirus B19 infection in sickle cell anemia and thalassemia patients.

Methods: Several online databases were searched including, Scopus, EMBASE, Web of Science, Google Scholar, and PubMed, which were performed amidst 2009-2019 by using distinct keywords: "Thalassemia," "Parvovirus," "Anemia," "Sickle cell anemia," "parvoviridae," "parvoviridae infection," and "parvovirus B19."

Results: Search results indicated 4 and 7 studies for the prevalence of the parvovirus B19 in β-thalassemia and SCD, respectively. Among the β-thalassemia patients, the B19V seroprevalence for IgG and IgM were ranged from 18.2-81% and 14.5-41.1%, respectively; meanwhile, B19V DNA positively results was 4-15.3%. Moreover, in the SCD group, the extent of B19V IgG was varied from 37.6 to 65.9% and that of IgM was in a range of 2.9-30%, and the DNA detection rate was 4-54%.

Conclusion: B19V seroprevalence changes in several conditions including, different epidemiological features, socio-economic status, and overpopulation. Age can expand the incidence of anti-B19V IgG/IgM in SCD and beta-thalassemia patients. Reinfection and diverse genotypes are relevant factors in the seroprevalence of B19v. The patients' immunological-hematological station and higher abundance of transfusions can affect the B19V seroprevalence in SCD and beta-thalassemia group. Further investigations in this field could be suggested to better understand the virus distribution in this susceptible population of patients.

Keywords: Parvovirus B19; Sickle cell anemia; β-thalassemia.

PubMed Disclaimer

Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Fig. 1
Fig. 1
Conducted study search flowchart
See this image and copyright information in PMC

References

    1. MAM CF, Maniloff J, Desselberger U, Ball LA. Virus taxonomy, classification, and nomenclature of viruses. In: CM Fauquet, editor. The eighth report of the International Committee on Taxonomy of Viruses. San Diego: Elsevier Academic Press; 2005. p. 655–68.
    1. Katta R. Parvovirus B19: a review. Dermatologic clinics. 2002;20(2):333–342. doi: 10.1016/s0733-8635(01)00013-4. - DOI - PubMed
    1. Cossart YE, Field AM, Cant B, Widdows D. Parvovirus-like particles in human sera. Lancet. 1975;1(7898):72–73. doi: 10.1016/s0140-6736(75)91074-0. - DOI - PubMed
    1. Pickering L, Baker C, Long S, McMillanassociate J. Parvovirus B19 (erythema infectiosum, fifth disease). Red Book: 2012 Report of the Committee on Infections Diseases. 2006. pp. 539–541.
    1. Servey JT, Reamy BV, Hodge J. Clinical presentations of parvovirus B19 infection. Am Fam Physician. 2007;75(3):373–376. - PubMed

LinkOut - more resources