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. 2020 Dec;4(12):1128-1133.
doi: 10.1038/s41551-020-00658-w.

Development of vaccines and antivirals for combating viral pandemics

Norbert Pardi  1 , Drew Weissman  2
Affiliations

Development of vaccines and antivirals for combating viral pandemics

Norbert Pardi et al. Nat Biomed Eng. 2020 Dec.

Abstract

Proactive efforts towards the development of new vaccines and antivirals, and the elimination of bottlenecks in vaccine development, will be essential to containing and eradicating future pandemics.

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Conflict of interest statement

Competing interests

The authors are named on patents that describe the use of nucleoside-modified mRNA as a platform to deliver therapeutic proteins and vaccines. These competing interests have been fully disclosed to the University of Pennsylvania, and an approved plan for managing any potential conflicts arising from the licensing of the patents is in place.

Figures

Fig. 1 |
Fig. 1 |. Prophylactic and therapeutic strategies against SARS-CoV-2.
a, Vaccine targets and vaccine platforms against SARS-CoV-2. b, Examples of viral targets and of potential antiviral drugs against SARS-CoV-2. ORF, open reading frame; RdRp, RNA-dependent RNA polymerase; PLpro, papain-like protease; ACE 2, angiotensin-converting enzyme 2; TMPRSS 2, transmembrane protease, serine 2; ERGIC, endoplasmic reticulum-Golgi intermediate compartment; IL-6R, interleukin-6 receptor.
See this image and copyright information in PMC

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