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. 2020 Dec 2:14:4209-4220.
doi: 10.2147/OPTH.S278589. eCollection 2020.

Comparative Analysis of Swept-Source Optical Coherence Tomography and Partial Coherence Interferometry Biometers in the Prediction of Cataract Surgery Refractive Outcomes

Arthur B Cummings  1 , Stephanie Naughton  1 , Ann-Marie Coen  1 , Elizabeth Brennan  1 , Gabrielle E Kelly  1
Affiliations

Comparative Analysis of Swept-Source Optical Coherence Tomography and Partial Coherence Interferometry Biometers in the Prediction of Cataract Surgery Refractive Outcomes

Arthur B Cummings et al. Clin Ophthalmol. .

Abstract

Purpose: To compare the accuracy of pre-operative corneal measurements obtained with four devices, and the refractive outcomes of two optical biometers.

Setting: Private practice.

Design: Retrospective.

Methods: Data taken from biometric measurements on 299 consecutive eyes prior to cataract surgery were retrospectively analyzed using the Argos SS-Optical Biometer and the Lenstar LS900 PCI optical biometer. As part of the standard cataract surgery pre-operative exam, patients also underwent placido disk topography and Scheimpflug tomography. Keratometry, anterior chamber depth, corneal diameter, pupil diameter, central corneal thickness and axial length were all measured. The comparable measurements were compared. Finally, for those eyes where cataract surgery was performed, the post-operative refractive results were compared to the predictive results of the two biometers.

Results: The SS-OCT Argos was able to measure all eyes, while five eyes could not be measured with the Lenstar LS900 PCI. Axial length measurements were performed only with the Argos and Lenstar devices. The eyes that could not be measured by the Lenstar LS900 PCI included dense grade IV nuclear sclerosis and large posterior subcapsular cataracts. In the primary endpoints, there was strong correlation between the Argos and the Lenstar devices in eyes with an axial length between 20 and 30 mm.

Conclusion: The predictive accuracies of the Argos Optical Biometer and Lenstar LS900 PCI are similar, except in medium and long eyes, in which the predictive accuracy of Argos SS-OCT biometry was higher. The Argos system was found easier to use by technicians when compared to the other biometry devices.

Keywords: OCT; cataract surgery; comparative analysis; partial coherence interferometry biometers; refractive outcomes.

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Conflict of interest statement

Arthur B Cummings reports that this was an IIT (Investigator Initiated Trial) that Alcon funded; and he is study PI for Allotex, on the MABs of Vivior, TearClear, TearLab, and Scope, outside the submitted work. The authors report no other conflicts of interest for this work.

Figures

Figure 1
Figure 1
Bland-Altman plot of AL for the Lenstar and Argos devices. Horizontal axis is the average of the two device readings in each eye while the vertical axis is the difference in measurements between the devices. Deming regression assumed the variance in measurement difference is four times larger than that in measurement average. Regression line parameters are shown in the bottom right of the graph.
Figure 2
Figure 2
Boxplots of axial length (AL) for Lenstar and Argos (1=Lenstar, 2=Argos). Median AL difference between devices=0.0. Wilcoxon signed rank test p-value=0.4797. Spearman correlation coefficient 0.9884 (p<0.0001).
Figure 3
Figure 3
Boxplots of corneal curvature (R1) demonstrating distribution of results for each system with 1=Lenstar, 2=Argos, 3=Oculyzer and 4=Topolyzer. The p-value for the F-test comparing all 4 biometers was 0.3216 (>0.05).
Figure 4
Figure 4
Boxplot of corneal curvature (R2) demonstrating distribution of results for each system with 1=Lenstar, 2=Argos, 3= Oculyzer and 4=Topolyzer. The p-value for the F-test comparing all 4 biometers was 0.0037 (<0.05).
Figure 5
Figure 5
Boxplots of central corneal thickness (CCT) demonstrating distribution of results for each system with 1=Lenstar, 2=Argos and 3= Oculyzer. The p-value for the F-test comparing all 3 biometers was <0.0001.
Figure 6
Figure 6
Boxplots of anterior chamber depth (ACD) demonstrating distribution of results for each system with 1=Lenstar, 2=Argos and 3=Oculyzer. The p-value for the F-test comparing all 3 biometers was <0.0001.
Figure 7
Figure 7
Boxplots of white-to-white (WTW) demonstrating distribution of results for each system with 1=Lenstar, 2=Argos and 4=Topolyzer. The p-value for the F-test comparing all 3 biometers was <0.0001.
Figure 8
Figure 8
Scatter plot showing excellent correspondence between pupil size as measured with Argos and Lenstar. Deming regression assumed that both measurements are made with errors that have equal variances. Regression line parameters are shown in the bottom right of the graph. The correlation is 0.86 with the Argos consistently measuring the pupil slightly smaller. This has no clinical significance.
Figure 9
Figure 9
Box-Plots of absolute error from the target value for devices Lenstar and Argos.
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References

    1. Rajan MS, Keilhorn I, Bell JA. Partial coherence laser interferometry vs conventional ultrasound biometry in intraocular lens power calculations. Eye. 2002;16(5):552–556. doi: 10.1038/sj.eye.6700157 - DOI - PubMed
    1. Raymond S, Favilla I, Santamaria L. Comparing ultrasound biometry with partial coherence interferometry for intraocular lens power calculations: a randomized study. Invest Ophthalmol Vis Sci. 2009;50:2547–2552. doi: 10.1167/iovs.08-3087 - DOI - PubMed
    1. Binkhorst RD. The accuracy of ultrasonic measurement of the axial length of the eye. Ophthalmic Surg. 1981;12:363–365. - PubMed
    1. Wolfgang D. Partial coherence interferometry: a novel approach to biometry in cataract surgery. Am J Ophthalmol. 1998;126(4):524–534. doi: 10.1016/S0002-9394(98)00113-5 - DOI - PubMed
    1. Omoto MK, Torii H, Masui S, et al. Ocular biometry and refractive outcomes using two swept-source optical coherence tomography-based biometers with segmental or equivalent refractive indices. Sci Rep. 2019;9:6557. doi: 10.1038/s41598-019-42968-3 - DOI - PMC - PubMed