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Review
. 2020 Dec 2:12:12385-12394.
doi: 10.2147/CMAR.S274599. eCollection 2020.

Multidrug Resistance of Gastric Cancer: The Mechanisms and Chinese Medicine Reversal Agents

Wen-Jie Huang #  1 , Shuai Ruan #  1 , Fang Wen  2 , Xiao-Na Lu  1 , Su-Ping Gu  2 , Xiao-Xue Chen  1 , Miao Liu  3 , Peng Shu  1
Affiliations
Review

Multidrug Resistance of Gastric Cancer: The Mechanisms and Chinese Medicine Reversal Agents

Wen-Jie Huang et al. Cancer Manag Res. .

Abstract

Chemotherapy is the main clinical treatment method of gastric cancer. Multidrug resistance (MDR) has become a common phenomenon with the development of tumors, which alleviates the effect of chemotherapy and makes it difficult to break the bottleneck of survival rate of advanced gastric cancer. Therefore, the exploration of MDR reversal agents for gastric cancer is the focus and also the difficulty of current treatment. Currently, the researches on the mechanisms of drug resistance in gastric cancer have been continuously deepened, which reveal different pathways and targets of MDR, laying a solid foundation for studying reversal agents. As a kind of natural medicine, traditional Chinese medicine (TCM) owns the characteristics of low toxicity, high safety and effectiveness. It can inhibit the occurrence, growth and metastasis of tumors, and reverse MDR via multiple pathways and mechanisms, the pathological function of which has become a research hotspot in recent years. TCM reversers are mainly divided into Chinese medicine monomers, Chinese patent medicines, and Chinese herbal compounds. With certain quantity and advantage, TCM reversers for MDR play an important role in the clinical treatment and show great potential in gastric cancer.

Keywords: MDR; TCM; gastric cancer; mechanisms; multidrug resistance; review; traditional Chinese medicine.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
The main mechanisms of gastric cancer MDR.
See this image and copyright information in PMC

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