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. 2021 Aug;27(9):1451-1454.
doi: 10.1177/1352458520978222. Epub 2020 Dec 9.

Clinical significance of a single cerebrospinal fluid immunoglobulin band: A retrospective study

Maud Tusseau  1 , Estelle Cheli  1 , Romain Marignier  2 , Françoise Poitevin  1 , Christophe Malcus  1 , Morgane Gossez  1 , Julien Bancel  1 , Guillaume Monneret  1 , Sandra Vukusic  3
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Clinical significance of a single cerebrospinal fluid immunoglobulin band: A retrospective study

Maud Tusseau et al. Mult Scler. 2021 Aug.

Abstract

Background: To demonstrate an inflammatory process in the central nervous system, the presence of at least two immunoglobulin (Ig) bands in the cerebrospinal fluid (CSF) is required. So far, the presence of a single abnormal Ig band is considered as negative.

Objective: The objective was to assess retrospectively the significance of a single CSF Ig band in clinical practice.

Methods and results: Out of 10,286 CSF analyses, we retained 214 results with single Ig. An inflammatory neurological disorder was diagnosed in 41% of patients.

Conclusion: Despite a modest sensitivity, the presence of a single CSF Ig band may be a biomarker of an inflammatory mechanism and, as such, may prompt the clinician to repeat the analysis when the clinical context remains suggestive.

Keywords: Multiple sclerosis; cerebrospinal fluid; immunoglobulin band; isoelectrofocalisation.

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