Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Apr 1;17(4):767-777.
doi: 10.5664/jcsm.9046.

The maturation changes of sleep-related respiratory abnormalities in infants with laryngomalacia

Woranart Ratanakorn  1   2 , Justin Brockbank  3 , Stacey Ishman  1   4   5   6 , Dawit G Tadesse  7 , Md Monir Hossain  4   7 , Narong Simakajornboon  1   4
Affiliations

The maturation changes of sleep-related respiratory abnormalities in infants with laryngomalacia

Woranart Ratanakorn et al. J Clin Sleep Med. .

Abstract

Study objectives: Obstructive sleep apnea (OSA) and central sleep apnea (CSA) are common in infants with laryngomalacia. The purpose of this study was to evaluate developmental changes in sleep-related breathing disorders over time in infants with laryngomalacia and understand the effect of supraglottoplasty (SGP) and nonsurgical treatment.

Methods: This is a retrospective review of infants with laryngomalacia who had at least 2 diagnostic polysomnography studies performed from January 2000 and May 2015. We included infants who had either OSA or CSA. Comparison of sleep and respiratory parameters by age group (0-6, 6-12, and >12 months old) was performed in both SGP and non-SGP groups using a mixed-effect regression model. A log-normal mixed model was used to explore the changes in sleep and respiratory parameters with age. The time to resolution of CSA and OSA was analyzed using nonparametric survival analysis.

Results: A total of 102 infants were included; 57 had only OSA and 45 had both CSA and OSA. There were significant decreases in apnea-hypopnea index, obstructive index, central apnea index, and arousal index with increasing age in both SGP and non-SGP groups. The mean age at resolution of CSA (central apnea index < 5) was 7.60 months old for SGP and 12.57 months old for non-SGP (P < .05). There were no significant differences in the mean age at resolution of OSA (obstructive index < 1; 35.18 [SGP] vs 41.55 months [non-SGP]; P = .60) between SGP and non-SGP groups. Infants with neurologic disease, congenital anomalies, or genetic syndromes required significantly more time to resolve OSA (28.12 [normal] vs 53.13 [neurological] vs 59.53 months [congenital anomalies and genetic]; P < .01).

Conclusions: Both OSA and CSA improve in infants with laryngomalacia with increasing age regardless of SGP. The mechanism underlying these changes may involve airway growth and maturation of respiratory control. Time to resolution of OSA is affected by the presence of neurologic diseases, congenital anomalies, and genetic syndromes. Further studies are needed to confirm these findings and to evaluate long-term outcomes in this population.

Keywords: central sleep apnea; developmental changes of sleep apnea; laryngomalacia; obstructive sleep apnea.

PubMed Disclaimer

Conflict of interest statement

All authors have seen and approved the manuscript. The study was funded by the Cincinnati Children’s Research Foundation. Part of this research was presented as an abstract at the International conference of the American Thoracic Society 2017. The authors report no conflicts of interest.

Figures

Figure 1
Figure 1. Mixed model.
Significant reduction in OI (top) and AHI (bottom) with increasing age without significant difference between the SGP and non-SGP groups. AHI = apnea-hypopnea index, LSM, least square mean, OI = obstructive index, SGP = supraglottoplasty.
Figure 2
Figure 2. Scatter diagram with log-normal mixed model.
Changes with age for AHI (top left), obstructive AHI (top right), central apnea index (bottom left), and arousal index (bottom right) in SGP and non-SGP. AHI = apnea-hypopnea index, SGP = supraglottoplasty
Figure 3
Figure 3. Kaplan-Meier curve (central sleep apnea).
Age at resolution of central sleep apnea (CI < 5) in infants with laryngomalacia comparing between SGP and non-SGP (left) and comparing infants with neurologic disease, congenital anomalies and syndrome, and infants with no underlying conditions (right). CI = central apnea index, SGP = supraglottoplasty, surv = survival probability.
Figure 4
Figure 4. Kaplan-Meier curve (obstructive sleep apnea).
Age at improvement of obstructive sleep apnea (OI < 1) in infants with laryngomalacia comparing between SGP and non-SGP (left) and comparing infants with neurological disease, congenital anomalies and syndrome, and infants with no underlying conditions (right). OI = obstructive index, SGP = supraglottoplasty, surv = survival probability.
See this image and copyright information in PMC

Comment in

References

    1. Daniel SJ. The upper airway: congenital malformations. Paediatr Respir Rev. 2006;7(Suppl 1):S260–S263. 10.1016/j.prrv.2006.04.227 - DOI - PubMed
    1. Thompson DM. Abnormal sensorimotor integrative function of the larynx in congenital laryngomalacia: a new theory of etiology. Laryngoscope. 2007117(6 Pt 2, Suppl 114:1–33. 10.1097/MLG.0b013e31804a5750 - DOI - PubMed
    1. Ramgopal S, Kothare SV, Rana M, Singh K, Khatwa U. Obstructive sleep apnea in infancy: a 7-year experience at a pediatric sleep center. Pediatr Pulmonol. 2014;49(6):554–560. 10.1002/ppul.22867 - DOI - PubMed
    1. Gonçalves MT, Sato J, Avelino MA, et al. Polisomnographic findings on children with laryngopathies. Braz J Otorhinolaryngol. 2006;72(2):187–192. 10.1016/S1808-8694(15)30054-9 - DOI - PMC - PubMed
    1. Tanphaichitr A, Tanphaichitr P, Apiwattanasawee P, Brockbank J, Rutter MJ, Simakajornboon N. Prevalence and risk factors for central sleep apnea in infants with laryngomalacia. Otolaryngol Head Neck Surg. 2014;150(4):677–683. 10.1177/0194599814521379 - DOI - PubMed

Publication types