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Review
. 2021 Jan;48(1):843-854.
doi: 10.1007/s11033-020-06056-4. Epub 2020 Dec 9.

Dynamic profile of the HBeAg-anti-HBe system in acute and chronic hepatitis B virus infection: A clinical-laboratory approach

Robério Amorim de Almeida Pondé  1   2
Affiliations
Review

Dynamic profile of the HBeAg-anti-HBe system in acute and chronic hepatitis B virus infection: A clinical-laboratory approach

Robério Amorim de Almeida Pondé. Mol Biol Rep. 2021 Jan.

Abstract

Wild-type HBV infection is followed by the blood expression of its widely known serological markers of infection, and designated as, hepatitis B virus surface antigen (HBsAg) and its antibody (anti-HBs), anti-HBc antibodies (IgM/IgG), and hepatitis B virus 'e' antigen (HBeAg) and its antibody (anti-HBe). These markers are detected as the infection develops and its kinetic behavior serves as a basis for monitoring the disorder and for diagnosing the clinical form or infection phase. Among these, the HBeAg-anti-HBe system markers demonstrate a dynamic profile whose interpretation, both in the acute or chronic HBV infection context, can offer greater difficulty to the health professionals, due to its particularities. This review offers a revisit to the markers dynamics of this system in the acute and chronic HBV infection and to the clinical and laboratory significance of its expression in these two clinical contexts.

Keywords: Acute HBV infection; Anti-HBe antibodies; Chronic HBV infection; HBe Antigen; Hepatitis B virus.

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References

    1. World Health Organization (2017) Global Hepatitis Report (2017) WHO, Geneva. https://apps.who.int/iris/bitstream/handle/10665 /25501 6/97892 41565 455-eng.pdf;jsessionid=E755A 57371 4A211 D864D 6FECC 4B18D 47?sequence=1
    1. Schillie S, Vellozzi C, Reingold A, Harris A, Haber P, Ward JW, Nelson NP (2018) Prevention of hepatitis B virus infection in the United States: recommendations of the advisory committee on immunization practices. MMWR Recomm Rep 67(1):1–31. https://doi.org/10.15585/mmwr.rr6701a1 - DOI - PubMed - PMC
    1. Kidd-Ljunggren K, Holmberg A, Bläckberg J, Lindqvist B (2006) High levels of hepatitis B virus DNA in body fluids from chronic carriers. J Hosp Infect 64(4):352–357 - PubMed
    1. Shih YF, Liu CJ (2017) Mother-to-infant transmission of hepatitis B virus: challenges and perspectives. Hepatol Int 11(6):481–484 - PubMed
    1. Ali BA, Huang TH, Salem HH, Xie QD (2006) Expression of hepatitis B virus genes in early embryonic cells originated from hamster ova and human spermatozoa transfected with the complete viral genome. Asian J Androl 8:273–279 - PubMed

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