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Review
. 2020 Dec;36(12):1129-1134.
doi: 10.1051/medsci/2020221. Epub 2020 Dec 9.

[Common cause and mechanism for all pathologies of aging?]

[Article in French]
Guillaume F Combes  1 , François-Xavier Pellay  2 , Miroslav Radman  1
Affiliations
Free article
Review

[Common cause and mechanism for all pathologies of aging?]

[Article in French]
Guillaume F Combes et al. Med Sci (Paris). 2020 Dec.
Free article

Abstract
in English, French

Health is harmony, aging and its diseases (are) functional disharmony at the molecular, cellular and tissue levels. Our observations lead us to think that there seems to be a common cause and a common mechanism for aging and its many and diverse diseases. This common cause is the oxidative damage to particular proteins emerging from a combination of imperfect folding and oxidative stress. This common cause jointly goes with the biological clock common to various age-related diseases, whose the incidence increases exponentially over time and causes 90% of human mortality. Pharmacological interventions on the common cause could avoid and simultaneously attenuate all degenerative and malignant diseases, as it is the natural case of super-centenarians.

Title: Cause commune et mécanisme commun aux maladies du vieillissement ?

Abstract: La santé est l’harmonie, le vieillissement et ses maladies la dysharmonie fonctionnelle aux niveaux moléculaire, cellulaire et tissulaire. Nos observations semblent suggérer une cause commune et un mécanisme commun du vieillissement et de ses nombreuses et diverses maladies. Cette cause commune est le dommage oxydatif de protéines particulières, résultant à la fois de leur mauvais repliement et du stress oxydatif. La cause commune va de pair avec l’horloge biologique des diverses maladies du vieillissement, dont l’incidence augmente exponentiellement avec l’âge, responsables de 90 % de la mortalité humaine. Des interventions pharmacologiques sur la cause commune pourraient éviter et atténuer simultanément toutes les maladies dégénératives et malignes, comme c’est le cas naturellement chez les super-centenaires.

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References

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