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Review
. 2020 Dec;36(12):1155-1162.
doi: 10.1051/medsci/2020223. Epub 2020 Dec 9.

[Functional integrity of aging skin, from cutaneous biology to anti-aging strategies]

[Article in French]
Julie Rorteau  1 , Fabien P Chevalier  1 , Bérengère Fromy  1 , Jérôme Lamartine  1
Affiliations
Review

[Functional integrity of aging skin, from cutaneous biology to anti-aging strategies]

[Article in French]
Julie Rorteau et al. Med Sci (Paris). 2020 Dec.

Abstract
in English, French

The skin is a sentinel organ making easily visible the passing of time. Chronological and environmental aging weakens skin structure and functions. The skin barrier, the elastic and mechanical properties of the cutaneous tissue as well as its vascular reactivity are impacted by aging. The barrier dysfunction in aged skin is caused by defects in epidermal keratinocytes renewal and differentiation notably linked to abnormal expression of microRNAs regulating cell death and autophagy. An abnormal balance between synthesis and degradation of matrix proteins modifies the mechanical properties of the dermis in aged skin. Finally, a reduction of the vascular reactivity linked to endothelial dysfunctions is observed in elderly people. These biological processes can be targeted by therapeutic approaches either topical or systemic, especially using anti-oxydants or senolytics. These anti-aging strategies might contribute to restore, at least in part, the functional integrity of aged skin.

Title: Vieillissement et intégrité de la peau - De la biologie cutanée aux stratégies anti-âge.

Abstract: La peau est un organe sentinelle, soumis au vieillissement chronologique et environnemental qui fragilise sa structure et ses fonctions. La fonction barrière de la peau, ses propriétés élastiques et de résistance, ainsi que sa réactivité vasculaire sont atteintes par le vieillissement dans les compartiments épidermiques, dermiques et vasculaires. Les progrès de la recherche ont permis de révéler des processus biologiques sous-jacents, qui peuvent être ciblés par des approches médicamenteuses topiques ou globales à base notamment d’anti-oxydants ou de sénolytiques. Ces stratégies anti-âge pourront contribuer à restaurer, au moins en partie, l’intégrité fonctionnelle de la peau âgée.

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References

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