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. 2020 Nov:46:102582.
doi: 10.1016/j.msard.2020.102582. Epub 2020 Oct 13.

Absence of latitudinal gradient in oligoclonal bands prevalence in Argentina

Laura Negrotto  1 , Mariano Marrodan  2 , Marcela P Fiol  2 , María I Gaitán  2 , María C Ysrraelit  2 , Carlos Vrech  3 , Agustín Pappolla  4 , Jimena Miguez  4 , Liliana Patrucco  4 , Edgardo Cristiano  5 , Juan I Rojas  6 , Adriana Carrá  7 , Aníbal Chertcoff  8 , Judith Steinberg  9 , Alejandra D Martinez  9 , María C Curbelo  9 , Leila Cohen  10 , Ricardo Alonso  11 , Orlando Garcea  10 , Cecilia Pita  10 , Berenice Silva  10 , Geraldine Luetic  12 , Norma Deri  13 , María E Balbuena  14 , Verónica Tkachuk  14 , Edgar Carnero Contentti  15 , Pablo A Lopez  15 , Juan Pablo Pettinicchi  15 , Alejandro Caride  15 , Marcos Burgos  16 , Felisa Leguizamon  17 , Eduardo Knorre  17 , Raúl Piedrabuena  18 , Andrés Barboza  19 , Susana Liwacki  20 , Pedro Nofal  21 , Gabriel Volman  22 , Amelia Alves Pinheiro  23 , Javier Hryb  24 , Darío Tavolini  25 , Patricio Blaya  26 , Luciano Recchia  27 , Carolina Mainella  28 , Matías Kohler  29 , Eduardo Kohler  29 , Jorge Blanche  30 , Santiago Tizio  31 , María L Saladino  32 , Fernando Caceres  32 , Nora Fernández Liguori  33 , Luciana Lazaro  34 , Gisela Zanga  35 , Marcela Parada Marcilla  36 , María E Fracaro  37 , Fátima Pagani Cassara  8 , Guido Vazquez  8 , Vladimiro Sinay  8 , Gustavo Sgrilli  38 , Pablo Divi  39 , Miguel Jacobo  39 , Emanuel Silva  40 , Edgardo Reich  41 , Lorena M Cabrera  42 , María L Menichini  43 , Mariano Coppola  44 , Iván Martos  45 , Juan Pablo Viglione  46 , Gustavo Jose  47 , Santiago Bestoso  48 , Rubén Manzi  49 , Diego Giunta  50 , María L Doldan  5 , Marina Alonso Serena  50 , Jorge Correale  2
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Absence of latitudinal gradient in oligoclonal bands prevalence in Argentina

Laura Negrotto et al. Mult Scler Relat Disord. 2020 Nov.

Abstract

Background: Like MS prevalence, oligoclonal bands (OCB) frequency seems to follow a latitudinal gradient. Argentina is extensive, latitude-wise, and previous studies have not found an MS prevalence latitudinal gradient. Our aim is to describe OCB prevalence in MS, clinically isolated syndrome (CIS) and radiologically isolated syndrome (RIS) patients included in the Argentinean MS and NMOSD registry (RelevarEM) and to investigate if it follows a latitudinal gradient.

Methods: For each province, an average latitude was calculated, and OCB frequency was investigated. Multivariate logistical regression analysis and linear correlation were performed. Statistical analysis was repeated after excluding patients from centers using isoelectric focusing (IEF) in less than 95% of patients (CwIEF<95).

Results: We included 2866 patients. OCB where positive in 73.9% of patients. No association or correlation were found between OCB and latitude of residence, even after excluding patients from (CwIEF<95).

Conclusion: OCB positivity does not follow a latitudinal gradient in Argentina. Also, OCB positivity is lower than described in other world regions.

Keywords: Clinically isolated syndrome; Epidemiology; Latitudinal gradient; Multiple sclerosis; Oligoclonal bands; Radiologically isolated syndrome.

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