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. 2020 Jan-Dec:19:1533033820980106.
doi: 10.1177/1533033820980106.

The Study of Tumor Volume as a Prognostic Factor in T Staging System for Non-Small Cell Lung Cancer: An Exploratory Study

Bei Jia  1   2   3 , Xu Zhang  1   2   3 , Yunxian Mo  2   4 , Biao Chen  1   2   3 , Hao Long  1   2   3 , Tiehua Rong  1   2   3 , Xiaodong Su  1   2   3
Affiliations

The Study of Tumor Volume as a Prognostic Factor in T Staging System for Non-Small Cell Lung Cancer: An Exploratory Study

Bei Jia et al. Technol Cancer Res Treat. 2020 Jan-Dec.

Abstract

Background: This study aimed to evaluate T staging system for non-small cell lung cancer (NSCLC) using tumor volume (TV) and other prognostic factors.

Methods: This study included 1309 cases. The TV and greatest tumor diameter (GTD) were semi-automatically measured. The receiver operating characteristic (ROC) curves of TV and GTD were used to predict survival. The regression analysis was used to describe the correlation between GTD and TV. Overall survival (OS) was analyzed using the Kaplan-Meier method. Cox's proportional hazards regression model was applied for multivariate analysis.

Results: Using the OS in pN0M0 patients (997 cases), we obtained 4 optimal cutoff values and divided all cases into 5 TV groups (V1: TV ≤ 2.80 cm3; V2: TV > 2.80-6.40 cm3; V3: TV > 6.40-12.9 cm3; V4: TV > 12.9-55.01 cm3; V5: TV > 55.01 cm3) with significant OS (P < 0.001). Multivariate analysis showed that age, visceral pleural invasion (VPI), and all TV cutoff points were independent factors of OS (P < 0.05). For V3 and V4 groups, the OS in patients without VPI was better than that in patients with VPI. Using the values of TV, VPI, and N stages, we classified all cases into 5 stages from I to V depending on the OS. The OS in I, II, III, IV, and V stages were 71.3%, 65.5%, 59.8%, 47.7%, and 35.1% respectively (P < 0.001).

Conclusions: We proposed a new T staging system using TV as the main prognostic descriptor in NSCLC patients, which may provide a better comprehensive clinical value than GTD in clinical applications.

Keywords: TNM staging system; greatest tumor diameter; non-small cell lung cancer; surgical resection; tumor volume.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
The flow chart of cases collection and screening. Abbreviations: NSCLC, non-small cell lung cancer; CT, computed tomography.
Figure 2.
Figure 2.
The area under the ROC curves for OS determined using TV and GTD. Abbreviations: ROC, receiver operating characteristic; OS, overall survival; TV, GTD.
Figure 3.
Figure 3.
The estimated curve for the correlation between TV and GTD. Abbreviations: TV, tumor volume; GTD, greatest tumor diameter.
Figure 4.
Figure 4.
The comparison of OS in pN0M0 patients using the cutoff points of 2.80 cm3, 6.40 cm3, 12.90 cm3 and 55.01 cm3, respectively. Abbreviations: OS, overall survival.
Figure 5.
Figure 5.
The comparison of OS in total patients based on the new TV staging system of I, II, III, IV and V. Abbreviations: OS, overall survival.
See this image and copyright information in PMC

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