The preliminary comparative results between Covid-19 and non-Covid-19 patients in Western China

Abstract

Background: This study aims to investigate the comparative clinical characteristics of Covid-19 and non-Covid-19 patients.

Methods: Fifteen Covid-19 and 93 non-Covid-19 patients were included in RNA testing. All epidemiological and clinical data were collected and analyzed, and then comparative results were carried out.

Results: Covid-19 patients were older (46.40 ± 18.21 years vs 34.43 ± 18.80 years) and had a higher body weight (70.27 ± 10.67 kg vs 60.54 ± 12.33 kg, P < 0.05). The main symptoms that were similar between Covid-19 and non-Covid-19 patients, and Covid-19 patients showed a lower incidence of sputum production (6.67% vs 45.16%, P < 0.01) and a lower white-cell count (4.83 × 10⁹/L vs 7.43 × 10⁹/L) and lymphocyte count (0.90 × 10⁹/L vs 1.57 × 10⁹/L, P < 0.01). Although there were no differences, C-reactive protein and interleukin-6 were elevated in Covid-19 patients. The sensitivity and negative predictive value of CT images were 0.87 and 0.97, respectively. Covid-19 patients showed a higher contact history of Wuhan residents (80% vs 30.11%) and higher familial clustering (53.33% vs 8.60%, P < 0.001). Covid-19 patients showed a higher major adverse events (ARDS, 13.33%; death, 6.67%; P < 0.05).

Conclusion: Our results suggested that Covid-19patients had a significant history of exposure and familial clustering and a higher rate of severe status; biochemical indicators showed lymphocyte depletion.

Keywords: Comparative results; Coronavirus; Covid-19; Epidemiology; Pneumonia.

Fig. 1

The chest CT images of the Covid-19 patient. CT images showed scattered exudative lesions in lungs, large ground-glass lesions, and partial consolidation of the lesions in the lower lobe of the left lung; a) transverse section; b) coronal section; c) median sagittal section