Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Dec 10;18(1):388.
doi: 10.1186/s12916-020-01859-5.

The global, regional, and national burden of pancreatitis in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017

Guoqing Ouyang  1 , Guangdong Pan  1 , Qiang Liu  1 , Yongrong Wu  1 , Zhen Liu  1 , Wuchang Lu  1 , Shuai Li  1 , Zheng Zhou  2 , Yu Wen  3
Affiliations

The global, regional, and national burden of pancreatitis in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017

Guoqing Ouyang et al. BMC Med. .

Abstract

Background: Pancreatitis is a critical public health problem, and the burden of pancreatitis is increasing. We report the rates and trends of the prevalence, incidence, and years lived with disability (YLDs) for pancreatitis at the global, regional, and national levels in 195 countries and territories from 1990 to 2017, stratified by sex, age, and sociodemographic index (SDI).

Methods: Data on pancreatitis were available from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017. Numbers and age-standardized prevalence, incidence, and YLDs' rates per 100,000 population were estimated through a systematic analysis of modeled data from the 2017 GBD study. Both acute and chronic pancreatitis are being modeled separately in the GBD 2017; however, our data show acute and chronic pancreatitis together. Estimates were reported with uncertainty intervals (UIs).

Results: Globally, in 2017, the age-standardized rates were 76.2 (95% UIs 68.9 to 83.4), 20.6 (19.2 to 22.1), and 4.5 (2.3 to 7.6) per 100,000 population for the point prevalence, incidence, and YLDs, respectively. From 1990 to 2017, the percent changes in the age-standardized prevalence and YLDs rates increased, whereas the age-standardized incidence rate decreased. The global prevalence increased with age up to 60-64 years and 44-49 years in females and males, respectively, and then decreased, with no significant difference between females and males. The global prevalence rate increased with age, peaking in the 95+ age group, with no difference between sexes. Generally, positive correlation between age-standardized YLDs and SDIs at the regional and national levels was observed. Slovakia (297.7 [273.4 to 325.3]), Belgium (274.3 [242.6 to 306.5]), and Poland (266.7 [248.2 to 284.4]) had the highest age-standardized prevalence rates in 2017. Taiwan (Province of China) (104.2% [94.8 to 115.2%]), Maldives (72.4% [66.5 to 79.2%]), and Iceland (64.8% [57.2 to 72.9%]) had the largest increases in age-standardized prevalence rates from 1990 to 2017.

Conclusions: Pancreatitis is a major public health issue worldwide. The age-standardized prevalence and YLDs rates increased, but the age-standardized incidence rate decreased from 1990 to 2017. Improving the quality of pancreatitis health data in all regions and countries is strongly recommended for better monitoring the burden of pancreatitis.

Keywords: Global Burden of Disease; Incidence; Pancreatitis; Prevalence; Years lived with disability.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
The age-standardized prevalence (a) and incidence rates (b) of pancreatitis in 2017 for 21 GBD regions, by sex
Fig. 2
Fig. 2
Age-standardized prevalence (a) and incidence rates (b) of pancreatitis per 100,000 population in 2017, by country and territory
Fig. 3
Fig. 3
Global cases and age-standardized rates of prevalence of pancreatitis per 100,000 population by age and sex, 2017. Shading indicates the upper and lower limits of the 95% uncertainty intervals (95% UIs)
Fig. 4
Fig. 4
Age-standardized YLDs rates for pancreatitis for 21 GBD regions by SDI, 1990–2017. Expected values based on Socio-demographic Index and disease rates in all locations are shown as the black line. YLDs = years lived with disability. GBD, Global Burden of Diseases, Injuries, and Risk Factors Study; SDI, sociodemographic index
Fig. 5
Fig. 5
Age-standardized YLDs rates for pancreatitis for 195 countries and territories by SDI, 2017. Expected values based on Socio-demographic Index and disease rates in all locations are shown as the black line. YLDs, years lived with disability; SDI, sociodemographic index
See this image and copyright information in PMC

References

    1. Hall TC, Garcea G, Webb MA, Al-Leswas D, Metcalfe MS, Dennison AR. The socio-economic impact of chronic pancreatitis: a systematic review. J Eval Clin Pract. 2014;20(3):203–207. doi: 10.1111/jep.12117. - DOI - PubMed
    1. Xiao AY, Tan ML, Wu LM, et al. Global incidence and mortality of pancreatic diseases: a systematic review, meta-analysis, and meta-regression of population-based cohort studies. Lancet Gastroenterol Hepatol. 2016;1(1):45–55. doi: 10.1016/S2468-1253(16)30004-8. - DOI - PubMed
    1. Yadav D, Lowenfels AB. The epidemiology of pancreatitis and pancreatic cancer. Gastroenterology. 2013;144(6):1252–1261. doi: 10.1053/j.gastro.2013.01.068. - DOI - PMC - PubMed
    1. Kleeff J, Whitcomb DC, Shimosegawa T, et al. Chronic pancreatitis. Nat Rev Dis Primers. 2017;3:17060. doi: 10.1038/nrdp.2017.60. - DOI - PubMed
    1. Petrov MS, Yadav D. Global epidemiology and holistic prevention of pancreatitis. Nat Rev Gastroenterol Hepatol. 2019;16(3):175–184. doi: 10.1038/s41575-018-0087-5. - DOI - PMC - PubMed

Publication types