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. 2021 Sep;42(9):1115-1117.
doi: 10.1017/ice.2020.1360. Epub 2020 Dec 10.

Change in hospital antibiotic use and acquisition of multidrug-resistant gram-negative organisms after the onset of coronavirus disease 2019

Jacqueline T Bork  1 , Surbhi Leekha  1   2 , Kimberly Claeys  3 , Hyunuk Seung  3 , Megan Tripoli  2 , Anthony Amoroso  1 , Emily L Heil  3
Affiliations

Change in hospital antibiotic use and acquisition of multidrug-resistant gram-negative organisms after the onset of coronavirus disease 2019

Jacqueline T Bork et al. Infect Control Hosp Epidemiol. 2021 Sep.

Abstract

Interrupted time series segmented regression was conducted to trend antibiotic use and multidrug-resistant gram-negative (MDRGN) acquisition relative to COVID-19 in an academic hospital. Total antibiotic use and antibiotic use related to pneumonia was higher in the period after the onset of COVID-19 compared to the similar calendar period in 2019. Furthermore, MDRGN acquisition increased 3% for every increase in positive COVID-19 tests per week.

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Figures

Fig. 1.
Fig. 1.
(a) Patient days relative to COVID-19–positive inpatients. (b) Antibiotic days of therapy per 1,000 patient days (DOT/PDs) over time. (c) Pneumonia antimicrobial days of therapy per 1,000 patient days (DOT/PDs) over time. (d) Early pneumonia (within 7 days of admission) antimicrobial days of therapy per 1,000 patient days (DOT/PDs) over time. Note. the observed values and predicted means (trend) are presented as circles (filled or not filled) and lines (solid or short dash), respectively.
Fig. 2.
Fig. 2.
Incidence of multidrug-resistant gram negatives per 10,000 patient days (DOT/PDs) over time. Note. The observed values and predicted means (trend) are presented as circles (filled or not filled) and lines (solid or short dash), respectively.
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