Recent progress in plant-gold nanoparticles fabrication methods and bio-applications

Abstract

The preparation of gold nanoparticles via green routes applying plant extracts as the reducing agents and stabilizers has received broad interest in the last decades. Plant-gold nanoparticles have been well-developed and applied in biochemical and medical research, but there are still challenges that must be overcome. The main challenges include the construction of chemically-robust plant-gold nanoparticles, the precise design of biomimetic surfaces to fabricate nanozymes with high catalytic activities, and the development of approaches to construct biosensors with high selectivities and sensitivities. The cores and surfaces of plant-gold nanoparticles must be considered, as well as their catalytic activities and biosensing mechanisms. This review highlights the latest achievements in plant-gold nanoparticle preparation, heterogeneous nucleation, and surface functionalization, while also focusing on their optical properties and various biological and catalytic activities. Moreover, their antioxidant and cell apoptosis mechanisms, and biological activities are described. Plant-gold nanoparticles have shown great potential in high-performance analytical assays, high-activity catalysts, effective intracellular imaging, and clinical treatment.

Keywords: Catalytic activity; Cell imaging; Clinical treatment; Gold nanoparticles; Plant extracts; Sensing; Surface chemistry.