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Comment
. 2021 Jan;11(1):OF5.
doi: 10.1158/2159-8290.CD-NB2020-110. Epub 2020 Dec 9.

Lorlatinib Outperforms Crizotinib in NSCLC

No authors listed
Comment

Lorlatinib Outperforms Crizotinib in NSCLC

No authors listed. Cancer Discov. 2021 Jan.

Abstract

The CROWN study suggests that lorlatinib is effective in patients newly diagnosed with advanced ALK-positive non-small cell lung cancer. In the phase III trial, patients treated with lorlatinib were twice as likely to be alive without disease progression after 1 year than those who received crizotinib-with slower progression of brain metastases.

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  • First-Line Lorlatinib or Crizotinib in Advanced ALK-Positive Lung Cancer.
    Shaw AT, Bauer TM, de Marinis F, Felip E, Goto Y, Liu G, Mazieres J, Kim DW, Mok T, Polli A, Thurm H, Calella AM, Peltz G, Solomon BJ; CROWN Trial Investigators. Shaw AT, et al. N Engl J Med. 2020 Nov 19;383(21):2018-2029. doi: 10.1056/NEJMoa2027187. N Engl J Med. 2020. PMID: 33207094 Clinical Trial.

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