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Comment
. 2021 Feb 1;116(2):274-275.
doi: 10.14309/ajg.0000000000001077.

Paradigm Shift: Functional Dyspepsia-A "Leaky Gut" Disorder?

Jan Tack  1   2   3   4 , Jolien Schol  2 , Karen Van den Houte  2 , I-Hsuan Huang  2 , Florencia Carbone  3
Affiliations
Comment

Paradigm Shift: Functional Dyspepsia-A "Leaky Gut" Disorder?

Jan Tack et al. Am J Gastroenterol. .

Abstract

For up to 2 decades, pathophysiological research in functional dyspepsia focused on gastric sensorimotor dysfunction underlying symptom generation. Recent pathophysiological research has focused on low-grade inflammation in the duodenal mucosa. Emerging evidence confirms a loss of mucosal integrity in the duodenum in functional dyspepsia, and this is confirmed in a confocal laser endomicroscopy study demonstrating altered mucosal barrier function and pyroptosis. This technique may help to establish underlying mechanisms and evaluate novel therapeutic approaches to functional dyspepsia.

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References

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