Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2020 Oct;12(5):492-496.
doi: 10.5114/jcb.2020.100383. Epub 2020 Oct 30.

Salvage high-dose-rate interstitial brachytherapy for perineal recurrence of prostate cancer after surgery and radiotherapy: a case report

Andrea Vavassori  1 , Stefano Durante  1 , Matteo Augugliaro  1 , Stefania Comi  2 , Raffaella Cambria  2 , Federica Cattani  2 , Roberta Lazzari  1 , Deliu Victor Matei  3 , Ottavio De Cobelli  3   4 , Roberto Orecchia  5 , Barbara Alicja Jereczek-Fossa  1   4
Affiliations
Case Reports

Salvage high-dose-rate interstitial brachytherapy for perineal recurrence of prostate cancer after surgery and radiotherapy: a case report

Andrea Vavassori et al. J Contemp Brachytherapy. 2020 Oct.

Abstract

Perineal seeding of tumor cells from prostate cancer (PCa) is very rare, and no standard treatment exists for this atypical presentation with no evidence of distant metastases. Local excision or external beam radiotherapy are used as local salvage treatments for such perineal masses, including those occurring after biopsy, surgery, or interstitial brachytherapy. We report on a patient who presented no evidence of disease and no late urinary or gastrointestinal toxicities at 58 months after receiving high-dose-rate brachytherapy (HDR-BT) for perineal recurrence of PCa after radical prostatectomy and salvage external beam radiotherapy. To the best of our knowledge, this is the first case treated with HDR-BT in this scenario.

Keywords: interstitial HDR brachytherapy; perineal prostate cancer recurrence; reirradiation.

PubMed Disclaimer

Conflict of interest statement

The authors report no conflict of interest.

Figures

Fig. 1
Fig. 1
Pre-brachytherapy MRI (A) and choline PET (B)
Fig. 2
Fig. 2
Implant (A, B) and treatment plan (C)
Fig. 3
Fig. 3
Follow-up at 2 years with axial (A) and sagittal (B) MRI
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Haddad FS, Somsin AA. Seeding and perineal implantation of prostatic cancer in the track of the biopsy needle: three case reports and a review of the literature. J Surg Oncol 1987; 35: 184-191. - PubMed
    1. Moul JW, Miles BJ, Skoog SJ et al. . Risk factors for perineal seeding of prostate cancer after needle biopsy. J Urol 1989; 142: 86-88. - PubMed
    1. Moul JW, Bauer JJ, Srivastava S et al. . Perineal seeding of prostate cancer as the only evidence of clinical recurrence 14 years after needle biopsy and radical prostatectomy: molecular correlation. Urology 1998; 51: 158-160. - PubMed
    1. Downey DB, Chin JL, Williams JC. Perineal prostate cancer seeding along needle tract following cryosurgery. Can J Urol 1999; 6: 823-825. - PubMed
    1. Volanis D, Neal DE, Warren AY et al. . Incidence of needle-tract seeding following prostate biopsy for suspected cancer: a review of the literature. BJU Int 2015; 115: 698-704. - PubMed

Publication types