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Case Reports
. 2020 Nov 28;16(2):268-272.
doi: 10.1016/j.radcr.2020.11.024. eCollection 2021 Feb.

Pheochromocytoma of the organ of Zuckerkandl

Hoang Di Thu Le  1 , Thai Thi My Hanh Nguyen  1 , Anh Vu Pham  2 , Cong Thuan Dang  3 , Thanh Thao Nguyen  1
Affiliations
Case Reports

Pheochromocytoma of the organ of Zuckerkandl

Hoang Di Thu Le et al. Radiol Case Rep. .

Erratum in

Abstract

Paragangliomas are uncommon neuroendocrine neoplasms that occur in characteristic locations. While parasympathetic paragangliomas are mainly located at the head and neck, sympathetic paragangliomas are mostly located below the neck. Among parasympathetic paragangliomas, pheochromocytomas are the most common. Ninety percent of cases of pheochromocytomas arise within the adrenal gland. We report a case of a 63-year-old woman with an extra-adrenal pheochromocytoma of the organ of Zuckerkandl detected by CT and MRI and subsequently confirmed by postoperative histology and immunohistochemistry.

Keywords: Histopathology; Immunohistochemical; MRI; Paraganglioma; Pheochromocytoma; Zuckerkandl.

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Figures

Fig 1
Fig. 1
Axial, sagittal and coronal T2-weighted half-Fourier acquisition single-shot turbo spin-echo (HASTE) images demonstrate a hyperintense retroperitoneal mass (arrows) on the right side of aorta, adjacent to the bifurcation (arrowhead).
Fig 2
Fig. 2
Axial unenhanced T1-weighted fat saturation MR image (B) shows a mass with avid enhancement (arrows) compared to unenhanced image (A).
Fig 3
Fig. 3
This mass has high-signal intensity on DWI (A) and low ADC values (B), consistent with diffusion restriction.
Fig 4
Fig. 4
Axial T1-weighted in-phase (A) and out-of-phase (B) MR images show lesion with no signal intensity drop on out-of-phase image.
Fig 5
Fig. 5
Hematoxylin – eosin staining x100 (A) and x400 (B) of the tumor tissue demonstrates that the mass includes chief cells with basophilic cells and sustentacular cells, creating “Zellballen” pattern.
Fig 6
Fig. 6
Immunohistochemical result show positive for chromogranin A (A), synaptophysin (B), S100 (C), IHC x100.
Fig 7
Fig. 7
Calretinin (A), HMB45 (B) and desmin (C) negative, IHCx40.
See this image and copyright information in PMC

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