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Case Reports
. 2020 Oct;10(5):e47-e50.
doi: 10.1212/CPJ.0000000000000753.

FOSMN: A possible TDP-43 proteinopathy to consider in a patient with facial sensory symptoms

Garazi Agirre-Beitia  1 , Ana Moreno-Estébanez  1 , Tirso González-Pinto González  1 , Borja Melgar Jiménez  1 , Iria Campos Rodríguez  1 , Laura Cabral Martínez  1 , Amaia Jauregui Barrutia  1 , Amaia González Eizaguirre  1 , Ivan Caballero Romero  1 , Joseba Bárcena Llona  1 , Juan Carlos Gómez-Esteban  1
Affiliations
Case Reports

FOSMN: A possible TDP-43 proteinopathy to consider in a patient with facial sensory symptoms

Garazi Agirre-Beitia et al. Neurol Clin Pract. 2020 Oct.
No abstract available

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Figures

Figure
Figure. Postmortem neuropathologic findings of our patient
(A) Trigeminal nucleus with atrophic and reduced neuronal population (arrows). (B) Axonal loss in the posterior roots of the spinal cord. (C) Axonal loss in the anterior roots of the spinal cord. (D) TDP-43–positive cytoplasmic inclusions in the lower motor neurons (arrows), observed by immunohistochemistry. TDP-43 = TAR-DNA binding protein.
See this image and copyright information in PMC

References

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    1. Ziso B, Williams TL, Walters RJL, et al. . Facial onset sensory and motor neuronopathy: further evidence for a TDP-43 proteinopathy. Case Rep Neurol 2015;7:95–100. - PMC - PubMed
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