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. 2021 Jan;47(1):389-396.
doi: 10.1111/jog.14541. Epub 2020 Dec 9.

Multiple endometrial polyps is associated with higher risk of chronic endometritis in reproductive-aged women

Luyan Guo  1 , Fang Gu  1 , Jinfeng Tan  2 , Lu Luo  1 , Jun Gao  1 , Canquan Zhou  1   3
Affiliations

Multiple endometrial polyps is associated with higher risk of chronic endometritis in reproductive-aged women

Luyan Guo et al. J Obstet Gynaecol Res. 2021 Jan.

Abstract

Aim: To determine whether single endometrial polyp (EP) or multiple EP (polyp number ≥ 6) are associated with chronic endometritis (CE).

Methods: From June 2017 to December 2018, this study enrolled a total of 277 patients, including 92 patients with multiple EP, 82 patients with a single EP and 103 patients without polyps who underwent hysteroscopic examination and polypectomy. Polyps and endometrium samples were obtained and subjected to immunohistochemistry for CD138 to identify plasma cells and CE was diagnosed as CD138-positive plasma cells greater than or equal to 5/high power field. The prevalence of CE was compared and analyzed using the logistic regression model.

Results: All baseline parameters were comparable among the three groups except that the prevalence of abnormal uterine bleeding (AUB) was much higher in both polyp groups than the non-polyp control. The prevalence of CE was significantly higher in the multiple EP group than in the single EP group (58.7% vs 28.0%, P < 0.001). There was no difference on the prevalence of CE between the single EP and the non-polyp groups (28.0% vs 29.1%, P = 0.872). Multivariable analysis revealed that AUB (adjusted OR 2.81, 95% CI 1.35-5.87) and multiple EP (adjusted OR 2.58, 95% CI 1.38-4.82) were independently associated with CE, while the single EP did not increase the odds of CE compared to the non-polyp group (adjusted OR 0.74, 95% CI 0.38-1.45).

Conclusion: Multiple EP were positively associated with CE among reproductive-aged women, suggesting a possible hidden etiopathogenetic link between chronic inflammation and multiple EP.

Keywords: chronic endometritis; endometrial polyp; infertility.

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References

    1. Fatemi HM, Kasius JC, Timmermans A et al. Prevalence of unsuspected uterine cavity abnormalities diagnosed by office hysteroscopy prior to in vitro fertilization. Hum Reprod 2010; 25: 1959-1965.
    1. Kodaman PH. Hysteroscopic polypectomy for women undergoing IVF treatment: When is it necessary? Curr Opin Obstet Gynecol 2016; 28: 184-190.
    1. Afifi K, Anand S, Nallapeta S, Gelbaya TA. Management of endometrial polyps in subfertile women: A systematic review. Eur J Obstet Gynecol Reprod Biol 2010; 151: 117-121.
    1. Paradisi R, Rossi S, Scifo MC, Dall'O' F, Battaglia C, Venturoli S. Recurrence of endometrial polyps. Gynecol Obstet Invest 2014; 78: 26-32.
    1. Gu F, Zhang H, Ruan S et al. High number of endometrial polyps is a strong predictor of recurrence: Findings of a prospective cohort study in reproductive-age women. Fertil Steril 2018; 109: 493-500.

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