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. 2020 Dec 10:9:e62659.
doi: 10.7554/eLife.62659.

Cell non-autonomous regulation of health and longevity

Hillary A Miller  1 , Elizabeth S Dean  2 , Scott D Pletcher  2 , Scott F Leiser  2   3
Affiliations

Cell non-autonomous regulation of health and longevity

Hillary A Miller et al. Elife. .

Abstract

As the demographics of the modern world skew older, understanding and mitigating the effects of aging is increasingly important within biomedical research. Recent studies in model organisms demonstrate that the aging process is frequently modified by an organism's ability to perceive and respond to changes in its environment. Many well-studied pathways that influence aging involve sensory cells, frequently neurons, that signal to peripheral tissues and promote survival during the presence of stress. Importantly, this activation of stress response pathways is often sufficient to improve health and longevity even in the absence of stress. Here, we review the current landscape of research highlighting the importance of cell non-autonomous signaling in modulating aging from C. elegans to mammals. We also discuss emerging concepts including retrograde signaling, approaches to mapping these networks, and development of potential therapeutics.

Keywords: C. elegans; D. melanogaster; aging; genetics; genomics; healthspan; insulin signaling; neuroscience; sensory perception.

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Conflict of interest statement

HM, ED, SP, SL No competing interests declared

Figures

Figure 1.
Figure 1.. Summary of the role energy balance and insulin signaling on cell non-autonomous modulation of longevity in C. elegans.
Mammalian orthologs are listed in parentheses. If there are no parentheses, the name is shared across taxa.
Figure 2.
Figure 2.. Summary of the role of proteostasis in cell non-autonomous modulation of longevity in C. elegans.
Mammalian orthologs are listed in parentheses. If there are no parentheses, the name is shared across taxa.
Figure 3.
Figure 3.. Summary of the role of perception on cell non-autonomous modulation of longevity in C. elegans.
Mammalian orthologs are listed in parentheses. If there are no parentheses, the name is shared across taxa.
Figure 4.
Figure 4.. Summary of the role energy balance and insulin signaling on cell non-autonomous modulation of longevity in Drosophila melanogaster.
Mammalian orthologs are listed in parentheses. If there are no parentheses, the name is shared across taxa.
Figure 5.
Figure 5.. Summary of the role of proteostasis in cell non-autonomous modulation of longevity in Drosophila melanogaster.
Mammalian orthologs are listed in parentheses. If there are no parentheses, the name is shared across taxa.
Figure 6.
Figure 6.. Summary of the role of perception on cell non-autonomous modulation of longevity in Drosophila melanogaster.
Mammalian orthologs are listed in parentheses. If there are no parentheses, the name is shared across taxa.
Figure 7.
Figure 7.. The intersection of cell non-autonomous signaling and aging in mammals.
Figure 8.
Figure 8.. Summary model.
See this image and copyright information in PMC

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