Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2020 Dec 9;28(6):769-770.
doi: 10.1016/j.chom.2020.11.009.

Varying the Constant: Mechanisms of Fc-Mediated Immunity to Influenza Virus

Jenna M Kastenschmidt  1 , Lisa E Wagar  2
Affiliations
Free article
Comment

Varying the Constant: Mechanisms of Fc-Mediated Immunity to Influenza Virus

Jenna M Kastenschmidt et al. Cell Host Microbe. .
Free article

Abstract

Antibodies are typically thought to mediate antiviral immunity by blocking host-cell infection. However, immunoglobulin G (IgG) can also stimulate antiviral responses through its constant region. A recent study in Nature (Bournazos et al., 2020) shows that modifying Fc binding affinities to better target FcɣRIIa enhances the influenza CD8 T cell response.

PubMed Disclaimer

Comment on

Substances

LinkOut - more resources