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. 2020 Dec 8;12(12):1190.
doi: 10.3390/pharmaceutics12121190.

Trans-Resveratrol Oral Bioavailability in Humans Using LipiSperse™ Dispersion Technology

David Briskey  1   2 , Amanda Rao  2
Affiliations

Trans-Resveratrol Oral Bioavailability in Humans Using LipiSperse™ Dispersion Technology

David Briskey et al. Pharmaceutics. .

Abstract

Resveratrol is a naturally produced compound that has been well researched for its potential health benefits. The primary hindrance towards resveratrol's therapeutic efficacy is its traditionally poor oral bioavailability. LipiSperse® is a novel delivery system designed to increase the dispersion of lipophilic ingredients, like resveratrol, in aqueous environments. This single-dose, double-blind, randomized study compared the pharmacokinetics of a commercially available resveratrol with (Veri-Sperse®) and without (Veri-te) the LipiSperse® delivery complex. Healthy adults randomly received a single dose of either 150 Veri-te, 75 Veri-Sperse®, or 150 mg Veri-Sperse®. Venous blood samples were taken prior to dosing in a fasted state and at 0.5, 1, 2, 3, 4, 5, 6, 8 and 24 h post supplementation. Plasma trans-resveratrol conjugates were measured by liquid-chromatography tandem mass spectrometry (LC-MS/MS). The area under the curve (AUC) (0-24 h), maximum concentration (Cmax), and time of maximum concentration (Tmax) of plasma conjugates were calculated. The 150 mg dose of Veri-Sperse® had a 2-fold increase in absorption (AUC) and a 3-fold increase in Cmax of trans-resveratrol conjugates compared to 150 mg Veri-te. There was no statistical difference between 75 Veri-Sperse and 150 mg Veri-te for AUC or Cmax of resveratrol conjugates. These findings provide support for the use of LipiSperse® to improve absorption of resveratrol.

Keywords: LipiSperse®; absorption; bioavailability; pharmacokinetics; resveratrol.

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Conflict of interest statement

The authors declare no conflict of interest. Gencor Pacific had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

Figures

Figure 1
Figure 1
Plasma concentration of the trans-resveratrol sulfate over 24 h after a single dose.
Figure 2
Figure 2
Plasma concentration of the trans-resveratrol glucuronide conjugates over 24 h after a single dose.
Figure 3
Figure 3
Plasma concentration for the sum of sulfate and glucuronide conjugates (all-trans-resveratrol) over 24 h after a single dose.
See this image and copyright information in PMC

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