Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Dec 8;25(24):5795.
doi: 10.3390/molecules25245795.

Hydrogel Properties and Their Impact on Regenerative Medicine and Tissue Engineering

Adam Chyzy  1 , Marta E Plonska-Brzezinska  1
Affiliations
Review

Hydrogel Properties and Their Impact on Regenerative Medicine and Tissue Engineering

Adam Chyzy et al. Molecules. .

Abstract

Hydrogels (HGs), as three-dimensional structures, are widely used in modern medicine, including regenerative medicine. The use of HGs in wound treatment and tissue engineering is a rapidly developing sector of medicine. The unique properties of HGs allow researchers to easily modify them to maximize their potential. Herein, we describe the physicochemical properties of HGs, which determine their subsequent applications in regenerative medicine and tissue engineering. Examples of chemical modifications of HGs and their applications are described based on the latest scientific reports.

Keywords: hydrogel; physicochemical properties; regenerative medicine; tissue engineering.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Types of pores in the material: (1) transport pores, (2) closed pores, (3) open pores.
Figure 2
Figure 2
Extracellular matrix localization in living tissue.
Figure 3
Figure 3
Example of self-healing mechanisms supported by (A) electrostatic interactions, (B) host–guest interactions, (C) hydrogen bonds, (D) hydrophobic interactions, (E) π–π stacking, (F) acylhydrazone bonds, (G) boronate-diol complexation, (H) Diels–Alder reaction, (I) disulfide bonds, and (J) imine bonds.
Figure 4
Figure 4
Sol–gel transition of a (A) pH-responsive HG and (B) thermoresponsive HG.
Figure 5
Figure 5
Illustration of the thermoresponsive mechanism of (A) PEP and (B) PEP-AG HGs. Adapted with permission from [102]. Copyright (2020) American Chemical Society.
Figure 6
Figure 6
Schematic illustration of photoresponsive HG with host–guest interactions. Reprinted with permission from [108].
Figure 7
Figure 7
Schematic preparation and application of paintable, conductive HGs. Reprinted with permission from [133].
Figure 8
Figure 8
Examples of 3D bioprinting methods. Reprinted with permission from [148].
See this image and copyright information in PMC

References

    1. Yang C., Gao L., Liu X., Yang T., Yin G., Chen J., Guo H., Yu B., Cong H. Injectable Schiff base polysaccharide hydrogels for intraocular drug loading and release. J. Biomed. Mater. Res. A. 2019;107:1909–1916. doi: 10.1002/jbm.a.36677. - DOI - PubMed
    1. Tian W., Han S., Huang X., Han M., Cao J., Liang Y., Sun Y. LDH hybrid thermosensitive hydrogel for intravaginal delivery of anti-HIV drugs. Artif. Cells Nanomed. Biotechnol. 2019;47:1234–1240. doi: 10.1080/21691401.2019.1596935. - DOI - PubMed
    1. Martínez-Martínez M., Rodríguez-Berna G., Bermejo M., Gonzalez-Alvarez I., Gonzalez-Alvarez M., Merino V. Covalently crosslinked organophosphorous derivatives-chitosan hydrogel as a drug delivery system for oral administration of camptothecin. Eur. J. Pharm. Biopharm. 2019;136:174–183. doi: 10.1016/j.ejpb.2019.01.009. - DOI - PubMed
    1. Tao G., Wang Y., Cai R., Chang H., Song K., Zuo H., Zhao P., Xia Q., He H. Design and performance of sericin/poly(vinyl alcohol) hydrogel as a drug delivery carrier for potential wound dressing application. Mater. Sci. Eng. C. 2019;101:341–351. doi: 10.1016/j.msec.2019.03.111. - DOI - PubMed
    1. Wu Z., Hong Y. Combination of the Silver-Ethylene Interaction and 3D Printing to Develop Antibacterial Superporous Hydrogels for Wound Management. ACS Appl. Mater. Interfaces. 2019;11:33734–33747. doi: 10.1021/acsami.9b14090. - DOI - PubMed

LinkOut - more resources