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Observational Study
. 2021 Jan;82(1):5-7.
doi: 10.1016/j.humimm.2020.11.006. Epub 2020 Dec 7.

HLA allele and haplotype frequencies in the Panamanian population

Alejandro Llanes  1 , Luis Ortiz  2 , Juan Moscoso  2 , Gina Gutiérrez  2 , Elena Blake  2 , Carlos M Restrepo  1 , Ricardo Lleonart  1 , Cesar Cuero  3 , Alejandro Vernaza-Kwiers  4
Affiliations
Observational Study

HLA allele and haplotype frequencies in the Panamanian population

Alejandro Llanes et al. Hum Immunol. 2021 Jan.

Abstract

In this study, we report for the first time HLA allele and haplotype frequencies in the modern Panamanian population at a two-field (four digits) resolution level. Reported frequencies were calculated from genotype data for the HLA-A, -B, -C, -DPB1, -DQB1 and -DRB1 loci of 462 healthy unrelated Panamanian adults of Hispanic ethnicity. In addition to providing new insights on the allelic structure of the Panamanian population and its origin, these data are critical for better planning of healthcare strategies in the country and for future research exploring the association with certain chronic and infectious diseases.

Keywords: Allele frequencies; HLA genotyping; Haplotype frequencies; Hispanic population; Panama.

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Conflict of interest statement

Declaration of Competing Interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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