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Review
. 2021 May;37(5):460-475.
doi: 10.1016/j.tig.2020.11.003. Epub 2020 Dec 7.

Forkhead Transcription Factors in Health and Disease

Laetitia Herman  1 , Anne-Laure Todeschini  1 , Reiner A Veitia  2
Affiliations
Review

Forkhead Transcription Factors in Health and Disease

Laetitia Herman et al. Trends Genet. 2021 May.

Abstract

Forkhead box (FOX) proteins belong to an evolutionarily conserved family of transcription factors that has evolved by gene/genome duplication. FOX family members have undergone sequence and regulatory diversification. However, they have retained some degree of functional redundancy, in addition to playing specific roles, both during development and in the adult. Genetic alterations or misregulation of FOX genes underlie human genetic diseases, cancer, and/or aging. In this review, we provide an updated overview of the main characteristics of the members of this family, in terms of breadth of expression, protein domain composition, evolution, and function.

Keywords: Forkhead transcription factors; cancer; forkhead box factors; human diseasen; transcription.

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